- Deriving dopaminergic neurons for clinical use. A practical approach.
Deriving dopaminergic neurons for clinical use. A practical approach.
Scientific reports (2013-03-16)
Rodolfo Gonzalez, Ibon Garitaonandia, Tatiana Abramihina, Gerald K Wambua, Alina Ostrowska, Mathew Brock, Alexander Noskov, Francesca S Boscolo, John S Craw, Louise C Laurent, Evan Y Snyder, Ruslan A Semechkin
PMID23492920
RÉSUMÉ
New small molecules that regulate the step-wise differentiation of human pluripotent stem cells into dopaminergic neurons have been identified. The steroid, guggulsterone, was found to be the most effective inducer of neural stem cells into dopaminergic neurons. These neurons are extensively characterized and shown to be functional. We believe this new approach offers a practical route to creating neurons of sufficient quality to be used to treat Parkinson's disease patients.