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Merck

PTRF triggers a cave in.

Cell (2008-01-15)
Rahul Chadda, Satyajit Mayor
RÉSUMÉ

Caveolae are small membrane invaginations important for cell signaling that are characterized by the presence of caveolin proteins. Hill et al. (2008) have now identified PTRF as a new constituent of the caveolar coat. In the absence of PTRF, caveolae flatten and caveolin-1 is released into the cell membrane, where it is rapidly internalized and degraded.