- MYB transcriptionally regulates the miR-155 host gene in chronic lymphocytic leukemia.
MYB transcriptionally regulates the miR-155 host gene in chronic lymphocytic leukemia.
Blood (2011-02-08)
Karin Vargova, Nikola Curik, Pavel Burda, Petra Basova, Vojtech Kulvait, Vit Pospisil, Filipp Savvulidi, Juraj Kokavec, Emanuel Necas, Adela Berkova, Petra Obrtlikova, Josef Karban, Marek Mraz, Sarka Pospisilova, Jiri Mayer, Marek Trneny, Jiri Zavadil, Tomas Stopka
PMID21296997
RÉSUMÉ
Elevated levels of microRNA miR-155 represent a candidate pathogenic factor in chronic B-lymphocytic leukemia (B-CLL). In this study, we present evidence that MYB (v-myb myeloblastosis viral oncogene homolog) is overexpressed in a subset of B-CLL patients. MYB physically associates with the promoter of miR-155 host gene (MIR155HG, also known as BIC, B-cell integration cluster) and stimulates its transcription. This coincides with the hypermethylated histone H3K4 residue and spread hyperacetylation of H3K9 at MIR155HG promoter. Our data provide evidence of oncogenic activities of MYB in B-CLL that include its stimulatory role in MIR155HG transcription.
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Normal Rabbit IgG, This Normal Rabbit IgG is validated for use as a negative control in parallel with specific primary antibodies in ELISA, FC, Immunoblotting, IF, IHC, IP.