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Key Documents

SRP8047

Sigma-Aldrich

Omentin human

recombinant, expressed in CHO cells, FLAG® tagged, >95% (SDS-PAGE)

Synonyme(s) :

ACRP30headless:TNFSF13, Endothelial lectin HL-1, Galactofuranose-binding Lectin, Intestinal lactoferrin receptor, Omentin 1

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About This Item

Numéro CAS:
786735-12-4
Code UNSPSC :
12352200
Nomenclature NACRES :
NA.32

Source biologique

human

Produit recombinant

expressed in CHO cells

Étiquette/Marqueur

FLAG® tagged

Pureté

>95% (SDS-PAGE)

Forme

lyophilized

Poids mol.

~38 kDa

Conditionnement

pkg of 10 μg

Conditions de stockage

avoid repeated freeze/thaw cycles

Technique(s)

ligand binding assay: suitable

Impuretés

<0.1 EU/μg endotoxin, tested

Couleur

white

Numéro d'accès UniProt

Q8WWA0

Conditions d'expédition

wet ice

Température de stockage

−20°C

Informations sur le gène

human ... ITLN1(55600)

Description générale

Omentin (intelectin-1) is highly expressed in omental adipose tissue, small intestine and various other tissues. It is a plasma adipokine made up of 313 amino acids.

Application

Omentin (intelectin-1) has been used in intelectin binding and cleavage assays.

Actions biochimiques/physiologiques

Omentin (intelectin-1) has no effect on basal glucose uptake but enhances insulin-stimulated glucose uptake in adipocytes. It increases protein kinase B (AKT) phosphorylation in the absence and presence of insulin. Omentin was suggested to play a role in the defense system against microorganisms by recognizing carbohydrate chains of pathogens and bacterial components containing galactofuranosyl residues. It has anti-inflammatory and insulin-sensitizing properties. The protein may be a biomarker of metabolic disorders. It has been shown to be over-expressed in human malignant pleural mesothelioma (MPM).

Forme physique

Lyophilized from PBS.

Reconstitution

Reconstitute with 100 μL deionized water.

Autres remarques

Human omentin (aa 17-313) is fused at the N-terminus to a FLAG®-tag.

Informations légales

FLAG is a registered trademark of Merck KGaA, Darmstadt, Germany

Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Michael Sigal et al.
Nature cell biology, 21(7), 812-823 (2019-06-27)
Wnt signalling stimulated by binding of R-spondin (Rspo) to Lgr-family members is crucial for gastrointestinal stem cell renewal. Infection of the stomach with Helicobacter pylori stimulates increased secretion of Rspo by myofibroblasts, leading to an increase in proliferation of Wnt-responsive
Chemoproteomic profiling of host and pathogen enzymes active in cholera.
Hatzios SK
Nature Chemical Biology, 12(4), 268-274 (2016)
Dan Li et al.
Oncotarget, 6(18), 16168-16182 (2015-05-13)
Recent evidence shows the emerging roles of intelectin 1 (ITLN1), a secretory lectin, in human cancers. Our previous studies have implicated the potential roles of ITLN1 in the aggressiveness of gastric cancer. Herein, we investigated the functions, downstream targets, and
Circulating levels of adipocytokine omentin-1 in patients with renal cell cancer.
Shen XD
Cytokine, 77, 50-55 (2016)
Identification of omentin as a novel depot-specific adipokine in human adipose tissue: possible role in modulating insulin action.
Yang RZ
American Journal of Physiology. Endocrinology and Metabolism, 290(6), E1253-E1261 (2006)
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