SRP8027

CD24 (mouse): FC (human)

recombinant, expressed in HEK 293 cells, >90% (SDS-PAGE)

• Synonyme(s) : M1/69-J11D heat stable antigen, NaMN adenylyltransferase 1, Nectadrin, X62 Heat stable antigen (HSA)
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.32

Propriétés

• Source biologique: mouse
• Produit recombinant: expressed in HEK 293 cells
• Pureté: >90% (SDS-PAGE)
• Forme: lyophilized
• Poids mol.: ~50 kDa by SDS-PAGE
• Conditionnement: pkg of 50 μg
• Impuretés: <0.06 EU/μg endotoxin, tested
• Numéro d'accès UniProt: P24807
• Conditions d'expédition: wet ice
• Température de stockage: −20°C
• Informations sur le gène: mouse ... CD24(100133941)

Description

Description générale

CD24 is a highly glycosylated protein expressed as glycosyl-phosphatidyl-inositol (GPI) anchored molecule. Widely expressed, mainly on T cells, B cells and is upregulated in numerous types of cancers. It has costimulatory activity for antigen specific T cell responses. Polymorphisms of human CD24 are associated with several autoimmune diseases. Recently a new role as negative regulator of the immune response has been reported. CD24-deficient mice are more sensitive to inflammatory responses. CD24 together with the membrane protein SIGLEC interacts with danger-associated molecular patterns (DAMPs), such as HMGB1, HSP90 or HSP70. CD24/SIGLEC complex may differentially regulate the host response to DAMPs and PAMPs (pathogen-associated molecular patterns).

Forme physique

Lyophilized from PBS.

Reconstitution

Reconstitute with 50 μL deionized water.

Autres remarques

Mouse CD24 (aa 27-52) is fused at the C-terminus to the Fc portion of human IgG1.

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable