SAB4200118

Anti-CYBB antibody produced in rabbit

~1.5 mg/mL, affinity isolated antibody

• Synonyme(s) : Anti-CGD, Anti-Cytochrome b-245, β polypeptide (chronic granulomatous disease), Anti-GP91-1, Anti-GP91-PHOX, Anti-NOX2
• Numéro MDL: MFCD02686174
• Code UNSPSC : 12352203
• Nomenclature NACRES : NA.41

Propriétés

• Source biologique: rabbit
• Conjugué: unconjugated
• Forme d'anticorps: affinity isolated antibody
• Type de produit anticorps: primary antibodies
• Clone: polyclonal
• Forme: buffered aqueous solution
• Poids mol.: antigen ~95 kDa
• Espèces réactives: human
• Conditionnement: antibody small pack of 25 μL
• Concentration: ~1.5 mg/mL
• Technique(s): western blot: 1.5-3.0 μg/mL using RAW264 cell extracts
• Numéro d'accès UniProt: P04839
• Conditions d'expédition: dry ice
• Température de stockage: −20°C
• Modification post-traductionnelle de la cible: unmodified
• Informations sur le gène: human ... CYBB(1536)

Description

Description générale

CYBB (cytochrome b-245), belongs to the family of NADPH oxidases, that catalyze the generation of the superoxide ion. It is a six-transmembrane glycoprotein, that binds heme, flavin and NADPH. CYBB associates with membrane-bound p22^phox to assemble the heavy subunit of flavocytochrome b558, the catalytic component of phagocyte NADPH oxidase. It also associates with four cytosolic components p47^phox, p67^phox, p40^phox and Rac2 required for NADPH oxidase activity. Homologs of the NOX protein family include the catalytic subunits NOX1, NOX3-5, Duox1 and Duox2. NOX2/gp91^phox is expressed in neutrophils and phagocytes.

Application

Anti-CYBB antibody produced in rabbit has been used in immunoblotting and western blotting.

Actions biochimiques/physiologiques

CYBB (also known as cytochrome b-245) promotes neurotoxic activation of microglia, that play a central role during neuroinflammatory states and in amyotrophic lateral sclerosis (ALS). NOX1, NOX3-5, Duox1 and Duox2 plays important roles in redox-dependent cell signaling, inflammation and in neurodegenerative diseases. In ALS mice, deletion of either NOX1 or NOX2 gene has significantly slowed disease progression and improved survival.

Forme physique

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable