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P0121

Sigma-Aldrich

Anti-Purinergic Receptor P2X3 antibody produced in rabbit

affinity isolated antibody, lyophilized powder

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Niveau de qualité

200

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

lyophilized powder

Espèces réactives

rat

Technique(s)

immunohistochemistry: suitable using rat embryo DRG
western blot: 1:200 using rat dorsal root ganglion (DRG) lysates

Numéro d'accès UniProt

P49654

Conditions d'expédition

dry ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

rat ... P2rx3(81739)

Catégories apparentées

Description générale

The P2X3 (purinergic receptor P2X 3) receptor is expressed in primary afferent neurons. It is a subtype of P2X receptors family of ligand-gated ion channels, activated by extracellular ATP (adenosine triphosphate).

Immunogène

peptide (C)VEKQSTDSGAYSIGH corresponding to residues 383-397 of rat P2rx3.

Application

Anti-Purinergic Receptor P2X3 antibody has been used in immunohistochemistry.

Actions biochimiques/physiologiques

The P2X3 (purinergic receptor P2X 3) plays a major role in the transmission of pain. Inducing P2X3 generates a desensitizing transient response and initiating P2X2/3 creates a relatively persistent response. P2X3 decreases the sympathetic tone in SH rats.

Description de la cible

The P2X3 receptor is highly expressed on nociceptive sensory neurons in dorsal root ganglia (DRG) as a homomer or as a heteromer (P2X3/P2X2). ATP released from damaged cells activates the P2X3 receptor to initiate nociceptive signals. Involvement of ATP in the mechanism of chronic pain contributes to P2X3 receptor as a possible target for the development of pain therapeutics.

Forme physique

Lyophilized from phosphate buffered saline, pH 7.4, containing 1% BSA and 0.05% sodium azide.

Reconstitution

Reconstitute the lyophilized vial with 50 μL or 200 μL deionized water, depending on package size. Further dilutions should be made using a carrier protein such as BSA (1-3%).

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Purinergic receptors in the carotid body as a new drug target for controlling hypertension.
Pijacka W, et al.
Nature Medicine, 22(10), 1151-1151 (2016)
P2X3 receptor involvement in endometriosis pain via ERK signaling pathway.
Ding S, et al.
PLoS ONE, 12(9), e0184647-e0184647 (2017)
LncRNA uc. 48+ is involved in diabetic neuropathic pain mediated by the P2X 3 receptor in the dorsal root ganglia.
Wang S, et al.
Purinergic Signaling, 12(1), 139-148 (2016)
Bradykinin contributes to sympathetic and pressor responses evoked by activation of skeletal muscle afferents P2X in heart failure.
Xing J and Li J
Cellular Physiology and Biochemistry, 39(6), 2101-2109 (2016)
F Florenzano et al.
Neuroscience, 115(2), 425-434 (2002-11-08)
ATP released in the extracellular space by neuronal injury can influence neighboring neurons via activation of purinergic receptors. In vitro data suggest the involvement of ATP and purinergic receptors as trophic agents in different biological events such as neuritogenesis and
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