O3639

Ondansetron hydrochloride dihydrate

≥98% (HPLC), powder

• Synonyme(s) : 1,2,3,9-Tetrahydro-9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-4H-carbazol-4-one hydrochloride, GR 38032F
• Formule empirique (notation de Hill): C₁₈H₁₉N₃O · HCl · 2H₂O
• Numéro CAS: 103639-04-9
• Poids moléculaire : 365.85
• Numéro MDL: MFCD00374371
• Code UNSPSC : 12352200
• ID de substance PubChem : 329818907
• Nomenclature NACRES : NA.32

Propriétés

• Niveau de qualité: 100
• Pureté: ≥98% (HPLC)
• Forme: powder
• Conditions de stockage: desiccated
• Couleur: white
• Solubilité: H₂O: >5 mg/mL
• Température de stockage: −20°C
• Chaîne SMILES: Cl[H].[H]O[H].[H]O[H].Cc1nccn1CC2CCc3c(C2=O)c4ccccc4n3C
• InChI: 1S/C18H19N3O.ClH.2H2O/c1-12-19-9-10-21(12)11-13-7-8-16-17(18(13)22)14-5-3-4-6-15(14)20(16)2;;;/h3-6,9-10,13H,7-8,11H2,1-2H3;1H;2*1H2
• Clé InChI: VRSLTNZJOUZKLX-UHFFFAOYSA-N
• Informations sur le gène: human ... HTR3A(3359)

Description

Application

Ondansetron hydrochloride dihydrate has been used as a 5-HT₃ antagonist to attenuate rostro ventromedial medulla (RVM)/cholecystokinin (CCK)-induced mechanical hypersensitivity and to block the effects of trichostatin A (TSA) on 5-HT₃ protein.

Actions biochimiques/physiologiques

Ondansetron, (3RS)-9-methyl-3-[(2-methyl-1H-imidazol-1-yl) methyl] 1,2,3,9-tetrahydro-4H-carbazol-4-one hydrochloride dehydrate acts as a selective 5-hydroxytryptamine type 3 (5-HT3) serotonin receptor antagonist. It is used as an antiemetic to control nausea and vomiting associated with chemotherapy and radiotherapy.

5-HT₃ serotonin receptor antagonist

Caractéristiques et avantages

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informations sur la sécurité

• Pictogrammes: GHS05,GHS06,GHS09
• Mention d'avertissement: Danger
• Mentions de danger: H301 - H318 - H410
• Conseils de prudence: P264 - P273 - P280 - P301 + P310 - P305 + P351 + P338 - P391
• Classification des risques: Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 2 - Eye Dam. 1
• Code de la classe de stockage: 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges