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E1631

Sigma-Aldrich

β-Estradiol 17-valerate

≥98% (HPLC), powder

Synonyme(s) :

1,3,5(10)-estratriène-3,17β-diol 17-pentanote

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About This Item

Formule empirique (notation de Hill):
C23H32O3
Numéro CAS:
979-32-8
Poids moléculaire :
356.50
Numéro Beilstein :
2480357
Numéro CE :
213-559-2
Numéro MDL:
MFCD00056541
Code UNSPSC :
41116107
ID de substance PubChem :
24894423
Nomenclature NACRES :
NA.77

product name

β-Estradiol 17-valerate, ≥98%

Source biologique

synthetic

Pureté

≥98%

Forme

powder

Technique(s)

ELISA: suitable

Solubilité

acetone: 25 mg/mL, hazy, colorless

Conditions d'expédition

ambient

Température de stockage

room temp

Chaîne SMILES 

CCCCC(=O)OC1CCC2C3CCc4cc(O)ccc4C3CCC12C

InChI

1S/C23H32O3/c1-3-4-5-22(25)26-21-11-10-20-19-8-6-15-14-16(24)7-9-17(15)18(19)12-13-23(20,21)2/h7,9,14,18-21,24H,3-6,8,10-13H2,1-2H3

Clé InChI

RSEPBGGWRJCQGY-UHFFFAOYSA-N

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Description générale

β-Estradiol 17-valerate is a synthetic estrogen.

Application

β-Estradiol 17-valerate has been used:
  • in an in-vivo assay, to synchronize the estrus cycle in athymic nude mice, to study the effect of recombinant pigment epithelium-derived factor (rPEDF) on induced ectopic fibroid lesions
  • to study the influence of ovarian hormones on type II cGMP-dependent protein kinase (Prkg2) expression in mice
  • to induce growth of estrogen-dependent tumor cells in athymic nude mice to establish a breast cancer mouse model

Actions biochimiques/physiologiques

Estradiol valerate is observed to be useful for treating menopausal climacteric symptoms. β-Estradiol 17-valerate is used as a source of 17β-estradiol (E2) in in vitro fertilization, hormone replacement therapy, contraceptive drugs, to study reproductive disorders in animal models. It serves as growth promoter in animal farming. β-Estradiol 17-valerate is also used to culture single-sex population among fish. Studies in rats show that β-Estradiol 17-valerate has negative effects on the estrus cycle pattern.

Pictogrammes

Health hazardEnvironment
GHS08,GHS09

Mention d'avertissement

Warning

Mentions de danger

H351,H361fd,H362,H410

Classification des risques

Aquatic Chronic 1 - Carc. 2 - Lact. - Repr. 2

Code de la classe de stockage

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de danger pour l'eau (WGK)

WGK 3

Équipement de protection individuelle

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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