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76904

Vecuronium bromide

Name: Vecuronium bromide
Brand: SIGMA

Synonyme(s) :

1-[(2β,3α,5α,16β,17β)-3,17-Bis(acetyloxy)-2-(1-piperidinyl)androstan-16-yl]-1-methyl-piperidinium bromide

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About This Item

Formule empirique (notation de Hill):

C₃₄H₅₇BrN₂O₄

Numéro CAS:

50700-72-6

Poids moléculaire :

637.73

Numéro Beilstein :

4837308

Numéro CE :

256-723-9

Numéro MDL:

MFCD00867762

Code UNSPSC :

51152000

ID de substance PubChem :

329767429

Nomenclature NACRES :

NA.77

Source biologique

synthetic

Pureté

≥97.0% (TLC)

Forme

powder or crystals

Groupe fonctionnel

carboxylic acid

Chaîne SMILES

[Br-].CC(=O)O[C@H]1C[C@@H]2CC[C@@H]3[C@H](CC[C@@]4(C)[C@H]3C[C@@H]([C@@H]4OC(C)=O)[N+]5(C)CCCCC5)[C@@]2(C)C[C@@H]1N6CCCCC6

InChI

1S/C34H57N2O4.BrH/c1-23(37)39-31-20-25-12-13-26-27(34(25,4)22-29(31)35-16-8-6-9-17-35)14-15-33(3)28(26)21-30(32(33)40-24(2)38)36(5)18-10-7-11-19-36;/h25-32H,6-22H2,1-5H3;1H/q+1;/p-1/t25-,26+,27-,28-,29-,30-,31-,32-,33-,34-;/m0./s1

Clé InChI

VEPSYABRBFXYIB-PWXDFCLTSA-M

Informations sur le gène

human ... CHRNA1(1134) , CHRNB1(1140) , CHRND(1144) , CHRNE(1145) , CHRNG(1146)

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Catégories apparentées

Produits biochimiques

Actions biochimiques/physiologiques

Vecuronium Bromide is an aminosteroidal neuromuscular blocking agent. It relaxes the skeletal muscle and decreases oxygen consumption during surgery. It competes with acetylcholine and bind to cholinergic receptors at neuromuscular junctions.

Conditionnement

Bottomless glass bottle. Contents are inside inserted fused cone.

Pictogrammes

GHS07

Mention d'avertissement

Warning

Mentions de danger

H302

Classification des risques

Acute Tox. 4 Oral

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Sigma-Aldrich

P9791

Phosphate de potassium monobasic

Magnesium sulfate enhances non-depolarizing muscle relaxant vecuronium action at adult muscle-type nicotinic acetylcholine receptor in vitro.

Hong Wang et al.

Acta pharmacologica Sinica, 32(12), 1454-1459 (2011-10-12)

To investigate the effect of magnesium sulfate and its interaction with the non-depolarizing muscle relaxant vecuronium at adult muscle-type acetylcholine receptors in vitro. Adult muscle-type acetylcholine receptors were expressed in HEK293 cells. Drug-containing solution was applied via a gravity-driven perfusion

Quantitative analysis of the aminosteroidal non-depolarizing neuromuscular blocking agent vecuronium by LC-ESI-MS: A Postmortem Investigation.

Shawn P Vorce et al.

Journal of analytical toxicology, 32(6), 422-427 (2008-07-26)

The apparent recreational use of an aminosteroidal non-depolarizing neuromuscular blocking agent, vecuronium, is reported in this postmortem investigation. A quantitative method for the analysis of vecuronium and its active metabolite, 3-desacetylvecuronium, in blood and tissue samples was developed using liquid

Potency of nondepolarizing muscle relaxants on muscle-type acetylcholine receptors in denervated mouse skeletal muscle.

Hong WANG et al.

Acta pharmacologica Sinica, 31(12), 1541-1546 (2010-11-26)

to investigate the changing resistance to nondepolarizing muscle relaxants (NDMRs) during the first month after denervation. the denervated and innervated skeletal muscle cells were examined on days 1, 4, 7, 14, 21, and 28 after denervation. Individual denervated and innervated

Neuromuscular block.

W C Bowman

British journal of pharmacology, 147 Suppl 1, S277-S286 (2006-01-13)

Descriptions of the South American arrow poisons known as curares were reported by explorers in the 16th century, and their site of action in producing neuromuscular block was determined by Claude Bernard in the mid-19th century. Tubocurarine, the most important

Comparison of motor-evoked potentials monitoring in response to transcranial electrical stimulation in subjects undergoing neurosurgery with partial vs no neuromuscular block.

W H Kim et al.

British journal of anaesthesia, 110(4), 567-576 (2013-02-05)

There have been no evidence-based comparisons of motor-evoked potential (MEP) monitoring with no and partial neuromuscular block (NMB). We compared the effects of different levels of NMB including no NMB on MEP parameters. MEP-monitored 120 patients undergoing neurosurgery were enrolled.

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