AB5511
Anti-Opioid Receptor Antibody, µ, pain
serum, Chemicon®
Synonyme(s) :
mu opiate receptor, opioid receptor, mu 1
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About This Item
Code UNSPSC :
12352203
eCl@ss :
32160702
Nomenclature NACRES :
NA.41
Produits recommandés
Source biologique
rabbit
Niveau de qualité
Forme d'anticorps
serum
Type de produit anticorps
primary antibodies
Clone
polyclonal
Espèces réactives
mouse, primate, rat, human
Fabricant/nom de marque
Chemicon®
Technique(s)
immunocytochemistry: suitable
immunohistochemistry: suitable
western blot: suitable
Numéro d'accès NCBI
Numéro d'accès UniProt
Conditions d'expédition
dry ice
Modification post-traductionnelle de la cible
unmodified
Informations sur le gène
human ... OPRM1(4988)
Description générale
Opiates derived from the opium poppy, Papaver somniferum, have been used for millenia for their anti-diarrheal, analgesic and euphoric properties. More recently, endogenous peptides, enkephalins, dynorphins, and endorphins, were found to bind to the same sites as opiate alkaloids. The receptors for the classical opioids are three related GPCRs, δ, κ, and µ (also known as OP1, OP2 and OP3, respectively), that activate Gi/o to reduce intracellular cAMP levels. Although most clinically used opioids function by activation of the µ opioid receptor, agonists of spinal δ opioid receptors have antinociceptive activity that is independent of µ. In addition, activation of δ increases locomotor activity, inhibits gastrointestinal motility, and decreases respiratory frequency (Dhawan et al., 1996). Agonists for δ opioid receptors also exhibit antidepressant-like activity in animal models (Broom et al., 2002).
Spécificité
Mu Opioid receptor.
Other species have not been tested.
Immunogène
Epitope: C-terminus
Synthetic peptide from the C-terminus of rat Mu Opioid receptor.
Application
Detect Opioid Receptor using this Anti-Opioid Receptor Antibody, µ, pain validated for use in IC, IH & WB.
Immunohistochemistry:
1:2,500-1:5,000 dilution of a previous lot was used.
Western blot:
1:1,000 dilution of a previous lot was used.
Immunocytochemistry:
1:2,500-1:5,000 dilution of a previous lot was used.
Optimal working dilutions must be determined by the end user.
1:2,500-1:5,000 dilution of a previous lot was used.
Western blot:
1:1,000 dilution of a previous lot was used.
Immunocytochemistry:
1:2,500-1:5,000 dilution of a previous lot was used.
Optimal working dilutions must be determined by the end user.
Research Category
Neuroscience
Neuroscience
Research Sub Category
Neuroinflammation & Pain
Neuroinflammation & Pain
Qualité
Evaluated by Western Blot on Human Liver lysate.
Western Blot Analysis:
1:500 dilution of this antibody detected Opioid Receptor on 10 µg of Human Liver lysate.
Western Blot Analysis:
1:500 dilution of this antibody detected Opioid Receptor on 10 µg of Human Liver lysate.
Description de la cible
45 kDa
Forme physique
Rabbit polyclonal serum in buffer containing 0.05% sodium azide.
Unpurified
Stockage et stabilité
Stable for 1 year at -20ºC from date of receipt.
Remarque sur l'analyse
Control
Spinal cord, liver lysate
Spinal cord, liver lysate
Autres remarques
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Informations légales
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Clause de non-responsabilité
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Code de la classe de stockage
10 - Combustible liquids
Classe de danger pour l'eau (WGK)
WGK 1
Certificats d'analyse (COA)
Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".
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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.
Mu opioid receptors are expressed on radial glia but not migrating neuroblasts in the late embryonic mouse brain.
Tim J Sargeant,Darren J Day,Eli M Mrkusich,Darren F Foo,John H Miller
Brain Research null
Compartment-specific modulation of GABAergic synaptic transmission by mu-opioid receptor in the mouse striatum with green fluorescent protein-expressing dopamine islands.
Miura, M; Saino-Saito, S; Masuda, M; Kobayashi, K; Aosaki, T
The Journal of Neuroscience null
Sex differences in ?-opioid receptor expression in trigeminal ganglia under a myositis condition in rats.
Zhang, X; Zhang, Y; Asgar, J; Niu, KY; Lee, J; Lee, KS; Schneider, M; Ro, JY
European Journal of Pain null
Seung Keun Back et al.
Pain, 123(1-2), 117-126 (2006-03-28)
The present study investigated whether the loss of spinal mu-opioid receptors following peripheral nerve injury is related to mechanical allodynia. We compared the quantity of spinal mu-opioid receptor and the effect of its antagonists, such as naloxone and CTOP, on
Response of striosomal opioid signaling to dopamine depletion in 6-hydroxydopamine-lesioned rat model of Parkinson's disease: a potential compensatory role.
Koizumi, H; Morigaki, R; Okita, S; Nagahiro, S; Kaji, R; Nakagawa, M; Goto, S
Frontiers in Cellular Neuroscience null
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