572888-M

SU1498

A potent, reversible, ATP-competitive and selective inhibitor of Flk-1 kinase (IC₅₀ = 700 nM), a vascular endothelial growth factor (VEGF) receptor kinase.

• Synonyme(s) : SU1498, (E)-3-(3,5-Diisopropyl-4-hydroxyphenyl)-2-[(3-phenyl-n-propyl)amino-carbonyl]acrylonitrile, VEGFR Tyrosine Kinase Inhibitor VIII, VEGFR2 Kinase Inhibitor X
• Formule empirique (notation de Hill): C₂₅H₃₀N₂O₂
• Poids moléculaire : 390.52
• Code UNSPSC : 12352200

Propriétés

• Niveau de qualité: 100
• Pureté: ≥95% (HPLC)
• Forme: solid
• Puissance: 700 nM IC₅₀
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; protect from light
• Couleur: pale yellow
• Solubilité: DMSO: 5 mg/mL
• Température de stockage: −20°C

Description

Description générale

A potent, reversible, ATP-competitive and selective inhibitor of Flk-1 kinase (IC₅₀ = 700 nM), a vascular endothelial growth factor (VEGF) receptor kinase. Also reduces the expression of ets-1, a transcription factor stimulated by VEGF. Has only a weak inhibitory effect on PDGF-receptor (IC₅₀ >50 µM), EGF-receptor (IC₅₀ >100 µM), and HER2 (IC₅₀ >100 µM) kinases. Acts as an angiogenesis inhibitor as shown by its activity in the chorioallantoic membrane (CAM) assay and in an in vivo VEGF-induced permeability assay.

A potent, reversible, ATP-competitive and selective inhibitor of Flk-1 kinase (IC₅₀ = 700 nM), a vascular endothelial growth factor (VEGF) receptor kinase. Has only a weak inhibitory effect on PDGF receptor (IC₅₀ >50 µM), EGF-receptor (IC₅₀ >100 µM), and HER-2 (IC₅₀ >100 µM) kinases. Acts as an angiogenesis inhibitor as shown by its activity in the chorioallantoic membrane (CAM) assay and in an in vivo VEGF-induced permeability assay.

Actions biochimiques/physiologiques

Primary Target
Flk-1 kinase

Avertissement

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Autres remarques

Arbiser, J.L., et al. 2000. Am. J. Pathol. 156, 1469.
Strawn, L.M., et al. 1996. Cancer Res. 56, 3540.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable