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Key Documents

COA/CoQ

12-555

Crosstide KK

Name: Crosstide KK
Brand: MM

Crosstide KK primarily used in Kinase Assays.

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About This Item

Code UNSPSC :

12352202

eCl@ss :

32160405

Nomenclature NACRES :

NA.42

Niveau de qualité

100

Fabricant/nom de marque

Upstate^®

Technique(s)

activity assay: suitable (kinase)

Numéro d'accès NCBI

NM_001033578.1
NM_013257.3
NM_170709.1

Numéro d'accès UniProt

Q96BR1

Conditions d'expédition

wet ice

Informations sur le gène

human ... SGK3(23678)

Actions biochimiques/physiologiques

Protein Target: SGK3

Target Sub-Family: AGC

Qualité

Routinely evaluated by phosphorylation using SGK3, active (Catalog # 14-647).

Stockage et stabilité

2 years at 4°C

Informations légales

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 1

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

GLUT4 translocation precedes the stimulation of glucose uptake by insulin in muscle cells: potential activation of GLUT4 via p38 mitogen-activated protein kinase.

R Somwar et al.

The Biochemical journal, 359(Pt 3), 639-649 (2001-10-24)

We previously reported that SB203580, an inhibitor of p38 mitogen-activated protein kinase (p38 MAPK), attenuates insulin-stimulated glucose uptake without altering GLUT4 translocation. These results suggested that insulin might activate GLUT4 via a p38 MAPK-dependent pathway. Here we explore this hypothesis

The antihyperglycemic drug alpha-lipoic acid stimulates glucose uptake via both GLUT4 translocation and GLUT4 activation: potential role of p38 mitogen-activated protein kinase in GLUT4 activation.

D Konrad et al.

Diabetes, 50(6), 1464-1471 (2001-05-26)

The cofactor of mitochondrial dehydrogenase complexes and potent antioxidant alpha-lipoic acid has been shown to lower blood glucose in diabetic animals. alpha-Lipoic acid enhances glucose uptake and GLUT1 and GLUT4 translocation in 3T3-L1 adipocytes and L6 myotubes, mimicking insulin action.

Mechanism of activation of protein kinase B by insulin and IGF-1.

D R Alessi et al.

The EMBO journal, 15(23), 6541-6551 (1996-12-02)

Insulin activated endogenous protein kinase B alpha (also known as RAC/Akt kinase) activity 12-fold in L6 myotubes, while after transfection into 293 cells PKBalpha was activated 20- and 50-fold in response to insulin and IGF-1 respectively. In both cells, the

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