07-178
Anti-Hox A9 Antibody
Upstate®, from rabbit
Synonyme(s) :
Anti-ABD-B, Anti-HOX1, Anti-HOX1.7, Anti-HOX1G
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About This Item
Code UNSPSC :
12352203
eCl@ss :
32160702
Nomenclature NACRES :
NA.41
Produits recommandés
Source biologique
rabbit
Niveau de qualité
Forme d'anticorps
purified immunoglobulin
Type de produit anticorps
primary antibodies
Clone
polyclonal
Espèces réactives
mouse, human
Fabricant/nom de marque
Upstate®
Technique(s)
electrophoretic mobility shift assay: suitable
immunocytochemistry: suitable
western blot: suitable
Isotype
IgG
Numéro d'accès NCBI
Numéro d'accès UniProt
Conditions d'expédition
wet ice
Modification post-traductionnelle de la cible
unmodified
Informations sur le gène
human ... HOXA9(3205)
Description générale
HOXA9 is a transcription factor with a central role in both haemopoiesis and leukaemia. High levels of HOXA9 expression in haemopoietic cells is a characteristic feature of acute myeloid leukaemia (AML), and may be sufficient to cause this disease. Overexpression of Hoxa-9 markedly expands hematopoietic stem cells. HOXA9 expression changes dramatically with age - a uniformly low level of expression during early adulthood is replaced by a frequently very high expression in adults over sixty.
Spécificité
Based on a BLAST search, the antibody will likely cross react with Newt, Coelacanth, Dog, Chicken, and Rat Hox A9; Antelope, Mouse and Guinea Pig Hox 1.7; Frog, human and Zebrafish Hox A-9B; and Kenyan Clawed Frog Hox B.1
Hox A9
Immunogène
GST fusion protein corresponding to residues 194-272 of mouse Hox A9
Application
Detect Hox A9 with Anti-Hox A9 Antibody (Rabbit Polyclonal Antibody), that has been shown to work in EMSA, WB, ICC.
Research Category
Epigenetics & Nuclear Function
Epigenetics & Nuclear Function
Research Sub Category
Transcription Factors
Transcription Factors
Qualité
Routinely evaluated by immunoblot on whole cell lysates of Hoxa9 immortalized HF1 myeloid progenitor cells
Description de la cible
36kDa
Forme physique
Format: Purified
Protein A chromatography
Protein A purified immunoglobulin presented in 0.02M phosphate buffer, pH 7.6, 0.25M NaCl, and 0.1% Sodium Azide before the addition of glycerol to 30%.
Stockage et stabilité
2 years at -20°C
Remarque sur l'analyse
Control
Hoxa9 immortalized HF1 cells
Hoxa9 immortalized HF1 cells
Informations légales
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Clause de non-responsabilité
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Code de la classe de stockage
10 - Combustible liquids
Classe de danger pour l'eau (WGK)
WGK 2
Certificats d'analyse (COA)
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Isolated Hoxa9 overexpression predisposes to the development of lymphoid but not myeloid leukemia.
Beachy, SH; Onozawa, M; Silverman, D; Chung, YJ; Rivera, MM; Aplan, PD
Experimental Hematology null
K R Calvo et al.
Molecular and cellular biology, 20(9), 3274-3285 (2000-04-11)
The genes encoding Hoxa9 and Meis1 are transcriptionally coactivated in a subset of acute myeloid leukemia (AML) in mice. In marrow reconstitution experiments, coexpression of both genes produces rapid AML, while neither gene alone generates overt leukemia. Although Hoxa9 and
Ryo Miyamoto et al.
eLife, 10 (2021-07-27)
HOXA9 is often highly expressed in leukemias. However, its precise roles in leukemogenesis remain elusive. Here, we show that HOXA9 maintains gene expression for multiple anti-apoptotic pathways to promote leukemogenesis. In MLL fusion-mediated leukemia, MLL fusion directly activates the expression
Leukemic fusion genes MLL/AF4 and AML1/MTG8 support leukemic self-renewal by controlling expression of the telomerase subunit TERT.
A Gessner,M Thomas,P Garrido Castro,L Buchler,A Scholz,T H Brummendorf,N Martinez Soria et al.
Leukemia null
Integrative epigenomic analysis identifies biomarkers and therapeutic targets in adult B-acute lymphoblastic leukemia.
Geng, H; Brennan, S; Milne, TA; Chen, WY; Li, Y; Hurtz, C; Kweon, SM; Zickl, L; Shojaee et al.
Cancer Discovery null
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