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Merck

NOS1

nitric oxide synthase 1 (neuronal)

Synonymes:
IHPS1, N-NOS, NC-NOS, NOS, bNOS, nNOS
Espèce(s):
ID UniProtKB:
ID du gène:
  • Human(4842) Summary: The protein encoded by this gene belongs to the family of nitric oxide synthases, which synthesize nitric oxide from L-arginine. Nitric oxide is a reactive free radical, which acts as a biologic mediator in several processes, including neurotransmission, and antimicrobial and antitumoral activities. In the brain and peripheral nervous system, nitric oxide displays many properties of a neurotransmitter, and has been implicated in neurotoxicity associated with stroke and neurodegenerative diseases, neural regulation of smooth muscle, including peristalsis, and penile erection. This protein is ubiquitously expressed, with high level of expression in skeletal muscle. Multiple transcript variants that differ in the 5' UTR have been described for this gene but the full-length nature of these transcripts is not known. Additionally, alternatively spliced transcript variants encoding different isoforms (some testis-specific) have been found for this gene.[provided by RefSeq, Feb 2011]
  • Mouse(18125) nitric oxide synthase 1, neuronal
  • Rat(24598) nitric oxide synthase 1, neuronal
  • Zebrafish(60658) nitric oxide synthase 1 (neuronal)
  • domestic cat(101100342) nitric oxide synthase 1 (neuronal)
  • cow(536132) nitric oxide synthase 1 (neuronal)
  • Horse(100051079) nitric oxide synthase 1 (neuronal)
  • dog(477498) nitric oxide synthase 1 (neuronal)
  • chicken(427721) nitric oxide synthase 1 (neuronal)
  • naked mole-rat(101711993) nitric oxide synthase 1 (neuronal)
  • Domestic Rabbit(100009243) nitric oxide synthase 1 (neuronal)
  • domestic guinea pig(100729682) nitric oxide synthase 1 (neuronal)

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Small Molecule - Antagonist

Référence du produit
Description
Espèce(s)
(−)-Thalidomide, >98%, solid,
Espèce(s)
human, mouse, rat
(+)-Thalidomide, ≥98% (HPLC), powder,
Espèce(s)
human, mouse, rat
Ammonium pyrrolidinedithiocarbamate, ~99%,
Espèce(s)
human
Melatonin, powder, ≥98% (TLC),
Espèce(s)
human
(±)-Thalidomide, ≥98%, powder,
Espèce(s)
human, mouse, rat

Antibodies

Référence du produit
Description
Espèces réactives
Application
Anticorps anti-nitrotyrosine, Upstate®, from rabbit,
Espèces réactives
all
Application
immunocytochemistry
immunohistochemistry

immunoprecipitation (IP)

western blot
Anticorps anti-nitrotyrosine, Chemicon®, from rabbit,
Espèces réactives
all, human, mouse
Application
immunohistochemistry
western blot
Anti-Nitrotyrosine antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
Espèces réactives
wide range
Application
ELISA
immunofluorescence

immunohistochemistry

microarray

western blot
Anti-Nitric Oxide Synthase I Antibody, serum, Chemicon®,
Espèces réactives
human, monkey, mouse, rat, sheep
Application
immunohistochemistry
western blot
Anti-Nitrotyrosine Antibody, clone 1A6, clone 1A6, Upstate®, from mouse,
Espèces réactives
vertebrates
Application
immunocytochemistry
immunohistochemistry

immunoprecipitation (IP)

western blot

Small Molecule - Inhibitor

Référence du produit
Description
Espèce(s)
Spermidine trihydrochloride, ≥98% (TLC),
Espèce(s)
human
4-Nitrocatechol, ≥96.0%,
Espèce(s)
rat
5-Methyl-2-nitroaniline, 95%,
Espèce(s)
rat
2,6-Di-tert-butyl-4-methylphenol, ≥99.0% (GC), powder,
Espèce(s)
rat, human
L-Arginine, from non-animal source, meets EP, USP testing specifications, suitable for cell culture, 98.5-101.0%,
Espèce(s)
rat, human

Kits

Référence du produit
Description
Espèce(s)
Nitric Oxide Synthase Detection System, Fluorimetric, sufficient for 200 reactions,
Espèce(s)
human

Small Molecule - Precursor

Référence du produit
Description
Espèce(s)
L-Arginine, from non-animal source, meets EP, USP testing specifications, suitable for cell culture, 98.5-101.0%,
Espèce(s)
rat, human
L-Arginine, ,
Espèce(s)
rat, human
L-Arginine, 99%, FCC, FG,
Espèce(s)
rat, human
L-Arginine, reagent grade, ≥98%,
Espèce(s)
rat, human
L-Arginine, BioUltra, ≥99.5% (NT),
Espèce(s)
rat, human

esiRNA

Référence du produit
Description
Espèce(s)
MISSION® esiRNA, targeting mouse Nos1,
Espèce(s)
mouse