MME
membrane metallo-endopeptidase
Synonymes:
CALLA, CD10, NEP, SFE
Espèce(s):
Human MME (4311), Mouse Mme (17380), Rat Mme (24590), chicken MME (425031), dog MME (477120), cow MME (536741), Horse MME (100053541), domestic cat MME (101087516), sheep MME (101112618), domestic guinea pig Mme (100724320) ...Plus
ID UniProtKB:
ID du gène:
- Human(4311) Summary: This gene encodes a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). This protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. It is a glycoprotein that is particularly abundant in kidney, where it is present on the brush border of proximal tubules and on glomerular epithelium. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. This gene, which encodes a 100-kD type II transmembrane glycoprotein, exists in a single copy of greater than 45 kb. The 5' untranslated region of this gene is alternatively spliced, resulting in four separate mRNA transcripts. The coding region is not affected by alternative splicing. [provided by RefSeq, Jul 2008]
- Mouse(17380) membrane metallo endopeptidase
- Rat(24590) membrane metallo-endopeptidase
- chicken(425031) membrane metallo-endopeptidase
- dog(477120) membrane metallo-endopeptidase
- cow(536741) membrane metallo-endopeptidase
- Horse(100053541) membrane metallo-endopeptidase
- domestic cat(101087516) membrane metallo-endopeptidase
- sheep(101112618) membrane metallo-endopeptidase
- domestic guinea pig(100724320) membrane metallo-endopeptidase
- naked mole-rat(101715828) membrane metallo-endopeptidase
- Domestic Rabbit(100009251) membrane metallo-endopeptidase
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ELISA
Antibodies
Référence du produit
Description
Espèces réactives
Application
Anticorps anti-néprilysine (endopeptidase neutre, Nep), serum, Chemicon®,
Espèces réactives
human, mouse, rat
Application
immunohistochemistry
western blot
western blot
Anti-Human CD10 (MEM-78) ColorWheel® Dye-Ready mAb, for use with ColorWheel® Dyes (Required, sold separately),
Espèces réactives
human
Application
flow cytometry
Monoclonal Anti-CD10 antibody produced in mouse, clone MEM-78, purified immunoglobulin, buffered aqueous solution,
Espèces réactives
human
Application
flow cytometry
Anti-CD10 antibody, Rabbit monoclonal, recombinant, expressed in HEK 293 cells, clone RM337, purified immunoglobulin,
Espèces réactives
human
Application
immunohistochemistry
Small Molecule - Inhibitor
Proteins
Référence du produit
Description
Espèce(s)
Neprilysin/CD10 human, recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE),
Espèce(s)
human