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Merck

ESR2

estrogen receptor 2 (ER beta)

Synonymes:
ER-BETA, ESR-BETA, ESRB, ESTRB, Erb, NR3A2
Espèce(s):
ID UniProtKB:
ID du gène:
  • Human(2100) Summary: This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. Some isoforms dominantly inhibit the activity of other estrogen receptor family members. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been fully characterized. [provided by RefSeq, Jul 2008]
  • Mouse(13983) estrogen receptor 2 (beta)
  • Rat(25149) estrogen receptor 2 (ER beta)
  • chicken(395575) estrogen receptor 2 (ER beta)
  • dog(403639) estrogen receptor 2 (ER beta)
  • Horse(100033964) estrogen receptor 2 (ER beta)
  • cow(281146) estrogen receptor 2 (ER beta)
  • domestic cat(101086317) estrogen receptor 2 (ER beta)
  • domestic guinea pig(100731304) estrogen receptor 2 (ER beta)
  • Goat(100860823) estrogen receptor 2 (ER beta)
  • Domestic Rabbit(100346748) estrogen receptor 2 (ER beta)
  • sheep(443066) estrogen receptor 2 (ER beta)

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Small Molecule - Activator

Référence du produit
Description
Espèce(s)
β-Nicotinamide-adénine-dinucléotide sodium salt, ,
Espèce(s)
human
β-Nicotinamide-adénine-dinucléotide hydrate, ≥95% (HPLC),
Espèce(s)
human
β-Nicotinamide adenine dinucleotide, pkg of 10 mg (per vial),
Espèce(s)
human
β-Nicotinamide adenine dinucleotide, pkg of 50 mg (per vial),
Espèce(s)
human
β-Nicotinamide-adénine-dinucléotide hydrate, suitable for cell culture, ≥96.5% (HPLC), ≥96.5% (spectrophotometric assay), from yeast,
Espèce(s)
human

Small Molecule - Agonist

Référence du produit
Description
Espèce(s)
ERB-041, ≥98% (HPLC),
Espèce(s)
human
17α-Ethynylestradiol 3-cyclopentyl ether, ,
Espèce(s)
human
Estrone, ≥99%,
Espèce(s)
human, mouse, rat

Small Molecule - Allosteric Modulator

Référence du produit
Description
Espèce(s)
Raloxifene hydrochloride, United States Pharmacopeia (USP) Reference Standard,
Espèce(s)
human
Raloxifene hydrochloride, solid,
Espèce(s)
human
Estramustine sodium phosphate, ,
Espèce(s)
human
Raloxifene Hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material,
Espèce(s)
human
Raloxifene hydrochloride, European Pharmacopoeia (EP) Reference Standard,
Espèce(s)
human

Small Molecule - Antagonist

Référence du produit
Description
Espèce(s)
Fulvestrant, >98% (HPLC),
Espèce(s)
human
2-Methoxyestradiol, powder,
Espèce(s)
human
Fulvestrant, United States Pharmacopeia (USP) Reference Standard,
Espèce(s)
human
Fulvestrant, European Pharmacopoeia (EP) Reference Standard,
Espèce(s)
human
Fulvestrant, European Pharmacopoeia (EP) Reference Standard,
Espèce(s)
human

Antibodies

Référence du produit
Description
Espèces réactives
Application
Anti-Estrogen Receptor β Antibody, clone 68-4, rabbit monoclonal, clone 68-4, Upstate®, from rabbit,
Espèces réactives
human
Application
immunoprecipitation (IP)
western blot
Monoclonal Anti-ESR2 antibody produced in mouse, ,
Espèces réactives
human, monkey, mouse
Application
ChIP
dot blot

flow cytometry

immunocytochemistry

immunofluorescence

immunohistochemistry

western blot
Anti-Estrogen Receptor-β antibody produced in rabbit, affinity isolated antibody,
Espèces réactives
human, mouse, rat
Application
ELISA
immunofluorescence

western blot
Anti-Estrogen Receptor β Antibody, clone 9.88, clone 9.88, from mouse,
Espèces réactives
human, mouse, rat
Application
immunoprecipitation (IP)
western blot
Anti-ESR2 antibody produced in rabbit, affinity isolated antibody,
Espèces réactives
human
Application
western blot

Small Molecule - Mixed Agonist/Antagonist

Référence du produit
Description
Espèce(s)
α-Estradiol, powder, ≥98% (TLC),
Espèce(s)
human, rat
β-Estradiol, meets USP testing specifications,
Espèce(s)
human, mouse, rat
β-Estradiol, BioReagent, powder, suitable for cell culture,
Espèce(s)
human, mouse, rat
β-Estradiol, ≥98%,
Espèce(s)
human, mouse, rat
β-Estradiol, powder, γ-irradiated, suitable for cell culture,
Espèce(s)
human, mouse, rat

esiRNA

Référence du produit
Description
Espèce(s)
MISSION® esiRNA, targeting human ESR2,
Espèce(s)
human