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Merck

ELANE

elastase, neutrophil expressed

Synonymes:
ELA2, GE, HLE, HNE, NE, PMN-E, SCN1
Espèce(s):
Human ELANE (1991), Mouse Elane (50701), Rat Elane (299606), sheep ELANE (101110841), domestic guinea pig Elane (100724414), cow ELANE (100126050), Horse ELANE (100462967), domestic cat ELANE (100301482), dog ELANE (442980)
ID UniProtKB:
P08246, P09649, Q6B0D9, Q6LDP5
ID du gène:
  • Human(1991) Summary: Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins. The product of this gene hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix following the protein's release from activated neutrophils. The enzyme may play a role in degenerative and inflammatory diseases by its proteolysis of collagen-IV and elastin of the extracellular matrix. This protein degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN). This gene is clustered with other serine protease gene family members, azurocidin 1 and proteinase 3 genes, at chromosome 19pter. All 3 genes are expressed coordinately and their protein products are packaged together into azurophil granules during neutrophil differentiation. [provided by RefSeq, May 2009]
  • Mouse(50701) elastase, neutrophil expressed
  • Rat(299606) elastase, neutrophil expressed
  • sheep(101110841) elastase, neutrophil expressed
  • domestic guinea pig(100724414) elastase, neutrophil expressed
  • cow(100126050) elastase, neutrophil expressed
  • Horse(100462967) elastase, neutrophil expressed
  • domestic cat(100301482) elastase, neutrophil expressed
  • dog(442980) elastase, neutrophil expressed

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Antibodies

Référence du produit
Description
Espèces réactives
Application
MABS461
Anticorps anti-élastase neutrophile, clone AHN-10, clone AHN-10, from mouse,
Espèces réactives
human
Application
immunocytochemistry
immunohistochemistry
immunoprecipitation (IP)
inhibition assay
radioimmunoassay
481001
Anti-Neutrophil Elastase Rabbit pAb, liquid, Calbiochem®,
Espèces réactives
human
Application
SAB5500151
Anti-Neutrophil Elastase antibody, Rabbit monoclonal, clone SP203, recombinant, expressed in proprietary host, affinity isolated antibody,
Espèces réactives
human
Application
immunohistochemistry
SAB5703017
Anti-Neutrophil Elastase (ELANE) Antibody, clone 8X4E6, Rabbit Monoclonal, ,
Espèces réactives
mouse
Application
immunofluorescence
immunohistochemistry
immunoprecipitation (IP)
western blot
ZRB1927
Anti-Neutrophil Elastase Antibody, clone 1B2 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Espèces réactives
human
Application
affinity binding assay
flow cytometry
immunocytochemistry
immunohistochemistry
western blot

Proteins

Référence du produit
Description
Espèce(s)
E8140
Élastase from human leukocytes, lyophilized powder, ≥50 units/mg protein (Bradford),
Espèce(s)
human
A6150
α1-Antitrypsin from human plasma, salt-free, lyophilized powder,
Espèce(s)
human

esiRNA

Référence du produit
Description
Espèce(s)
EHU003711
MISSION® esiRNA, targeting human ELANE,
Espèce(s)
human