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Merck

CYP11B1

cytochrome P450, family 11, subfamily B, polypeptide 1

Synonymes:
CPN1, CYP11B, FHI, P450C11
Espèce(s):
Human CYP11B1 (1584), Mouse Cyp11b1 (110115), Rat Cyp11b1 (500892), domestic guinea pig Cyp11b1 (100135511), sheep CYP11B1 (767576), cow CYP11B1 (282422)
ID UniProtKB:
P15538, Q14095, Q4VAQ8, Q4VAQ9, Q9UML2
ID du gène:
  • Human(1584) Summary: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane and is involved in the conversion of progesterone to cortisol in the adrenal cortex. Mutations in this gene cause congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency. Transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jul 2008]
  • Mouse(110115) cytochrome P450, family 11, subfamily b, polypeptide 1
  • Rat(500892) cytochrome P450, family 11, subfamily b, polypeptide 1
  • domestic guinea pig(100135511) cytochrome P450, family 11, subfamily b, polypeptide 1
  • sheep(767576) cytochrome P450, family 11, subfamily B, polypeptide 1
  • cow(282422) cytochrome P450, subfamily XI B, polypeptide 1

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Antibodies

Référence du produit
Description
Espèces réactives
Application
ZRB2564
Anti-CYP11B1 Antibody, clone 1J14 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Espèces réactives
human, monkey
Application
affinity binding assay
immunofluorescence
immunohistochemistry
western blot
HPA056348
Anti-CYP11B1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Espèces réactives
human
Application
immunohistochemistry
MAB6020
Anti-Cytochrome P450 11β-Hydroxylase Antibody, clone 11B2-1A4, culture supernatant, clone 11B2-1A4, Chemicon®,
Espèces réactives
rat
Application
immunohistochemistry
western blot
SAB1303151
ANTI-CYP11B1 (C-TERM) antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution,
Espèces réactives
human
Application
flow cytometry
immunohistochemistry
western blot

Small Molecule - Inhibitor

Référence du produit
Description
Espèce(s)
35485
2,4′-DDD, PESTANAL®, analytical standard,
Espèce(s)
human
1445007
1-(2-Chlorophenyl)-1-(4-chlorophenyl)-2,2-dichloroethane, United States Pharmacopeia (USP) Reference Standard,
Espèce(s)
human
44012
1-(2-Chlorophenyl)-1-(4-chlorophenyl)-2,2-dichloroethane, certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland,
Espèce(s)
human
K1003
Ketoconazole, 99.0-101.0% (EP, titration),
Espèce(s)
mouse, human, rat
UC280
Ketoconazole, ,
Espèce(s)
mouse, human, rat

esiRNA

Référence du produit
Description
Espèce(s)
EHU140441
MISSION® esiRNA, targeting human CYP11B1,
Espèce(s)
human