CDKN2A
cyclin-dependent kinase inhibitor 2A
Synonymes:
ARF, CDK4I, CDKN2, CMM2, INK4, INK4A, MLM, MTS-1, MTS1, P14, P14ARF, P16, P16-INK4A, P16INK4, P16INK4A, P19, P19ARF, TP16
Espèce(s):
Human CDKN2A (1029), Mouse Cdkn2a (12578), Rat Cdkn2a (25163), chicken CDKN2A (395077), dog CDKN2A (100271861), cow CDKN2A (616369), domestic cat CDKN2A (101089220), domestic guinea pig Cdkn2a (100731972)
ID UniProtKB:
ID du gène:
- Human(1029) Summary: This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene. [provided by RefSeq, Sep 2012]
- Mouse(12578) cyclin-dependent kinase inhibitor 2A
- Rat(25163) cyclin-dependent kinase inhibitor 2A
- chicken(395077) cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)
- dog(100271861) cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)
- cow(616369) cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)
- domestic cat(101089220) cyclin-dependent kinase inhibitor 2A
- domestic guinea pig(100731972) cyclin-dependent kinase inhibitor 2A
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Antibodies
Référence du produit
Description
Espèces réactives
Application
Anti-p16-INK4a Antibody, clone 5F22 Antibody, ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Espèces réactives
human, mouse
Application
affinity binding assay
immunocytochemistry
immunohistochemistry
western blot
immunocytochemistry
immunohistochemistry
western blot
Anti-p16 INK antibody produced in rabbit, affinity isolated antibody,
Espèces réactives
human, mouse
Application
ELISA
western blot
western blot
Anti-CDKN2A/p16INK4a antibody produced in rabbit, ,
Espèces réactives
human, mouse, rat
Application
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot
p16 INK4a Rabbit Monoclonal Antibody, clone RM409, affinity purified immunoglobulin,
Espèces réactives
human
Application
immunohistochemistry
western blot
western blot
Anticorps anti-p16, clone D25, clone D25, Chemicon®, from mouse,
Espèces réactives
human
Application
immunohistochemistry
western blot
western blot
Small Molecule - Inhibitor
Proteins
Référence du produit
Description
Espèce(s)
p16-INK-4a human, recombinant, expressed in E. coli, ≥95% (SDS-PAGE), ≥95% (HPLC), suitable for cell culture,
Espèce(s)
human
p16-INK-4a TAT human, recombinant, expressed in E. coli, ≥95% (SDS-PAGE), ≥95% (HPLC), suitable for cell culture,
Espèce(s)
human
esiRNA
Référence du produit
Description
Espèce(s)