Accéder au contenu
Merck

CASP5

caspase 5, apoptosis-related cysteine peptidase

Synonymes:
ICE(rel)III, ICEREL-III, ICH-3
Espèce(s):
Human CASP5 (838)
ID UniProtKB:
P51878, B4DKP5, Q0QVY7, Q0QVY8, Q0QVZ0, Q0QVZ1, Q0QVZ2, Q14DD6
ID du gène:
  • Human(838) Summary: This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. Overexpression of the active form of this enzyme induces apoptosis in fibroblasts. Max, a central component of the Myc/Max/Mad transcription regulation network important for cell growth, differentiation, and apoptosis, is cleaved by this protein; this process requires Fas-mediated dephosphorylation of Max. The expression of this gene is regulated by interferon-gamma and lipopolysaccharide. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Aug 2010]

Custom & Knockdown Gene Products

  • siRNA

    Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.

  • shRNA

    Shop the largest, most validated shRNA collection and build your own clone sets.

  • Custom Gene Products

    We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.

Antibodies

Référence du produit
Description
Espèces réactives
Application
HPA040937
Anti-CASP5 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Espèces réactives
human
Application
immunohistochemistry
ABS445
Anti-Caspase-5 Antibody, from rabbit, purified by affinity chromatography,
Espèces réactives
human
Application
immunocytochemistry
immunofluorescence
western blot
PRS3455
Anti-Caspase-5 (ab1) antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
Espèces réactives
human
Application
ELISA
western blot
SAB4503304
Anti-CASP5 (p10, Cleaved-Ser331) antibody produced in rabbit, affinity isolated antibody,
Espèces réactives
human
Application
ELISA
western blot

Proteins

Référence du produit
Description
Espèce(s)
C6482
Caspase 5 human, recombinant, expressed in E. coli, 5,000 units/mg protein,
Espèce(s)
human

esiRNA

Référence du produit
Description
Espèce(s)
EHU127011
MISSION® esiRNA, targeting human CASP5,
Espèce(s)
human