- p62/SQSTM1 levels predicts radiotherapy resistance in hypopharyngeal carcinomas.
p62/SQSTM1 levels predicts radiotherapy resistance in hypopharyngeal carcinomas.
American journal of cancer research (2017-05-05)
Akihito Arai, Tokuhiro Chano, Kaichiro Ikebuchi, Yusuke Hama, Yasuko Ochi, Hitosuke Tameno, Taketoshi Shimada
PMID28469960
ABSTRACT
Hypopharyngeal carcinoma is one of the worst prognostic malignancies among head and neck carcinomas. Therefore, a good biomarker should be identified to predict the best therapeutic option before starting the treatment. In cell models, p62/SQSTM1 levels affected the Nrf2-Keap1 pathway, ROS levels, GSH/GSSG ratios and cell growth, especially under irradiation rather than under CDDP exposure, which was toxic despite p62/SQSTM1 status. In a clinical cohort of hypopharyngeal carcinomas, high levels of p62/SQSTM1 significantly predicted poor prognosis (log-rank test, Chi-square value = 6.750,
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