- Azathioprine induced serious portal hypertension: a case series of three IBD patients and review of the literature.
Azathioprine induced serious portal hypertension: a case series of three IBD patients and review of the literature.
Acta gastro-enterologica Belgica (2013-11-23)
D Dooremont, J Decaestecker, D De Wulf, G Ghillebert, H Van Vlierberghe, J Van Dorpe, F Baert
PMID24261031
ABSTRACT
We report 3 male IBD patients (2 Crohn's Disease, 1 Ulcerative Colitis) developing thrombocytopenia and splenomegaly on azathioprine treatment. All patients were diagnosed with significant portal hypertension due to histological proven nodular regenerative hyperplasia (NRH) of the liver. In two of three patients, liver function tests remained completely normal. In addition we provide a short literature review of azathioprine induced NRH covering etiology, imaging, pathology, prognosis and treatment.