- Inhibitory effect of triterpenes from Crataegus pinatifida on HIV-I protease.
Inhibitory effect of triterpenes from Crataegus pinatifida on HIV-I protease.
Planta medica (1999-06-12)
B S Min, H J Jung, J S Lee, Y H Kim, S H Bok, C M Ma, N Nakamura, M Hattori, K Bae
PMID10364847
ABSTRACT
The methanol extracts of the leaves of Crataegus pinnatifida showed potent inhibitory activities against HIV-1 protease at a concentration of 100 micrograms/ml. The subsequent fractionation and isolation of the extract gave two active compounds. Their structures were identified as uvaol (1) and ursolic acid (2) by spectral data. These active compounds inhibit HIV-1 protease with IC50 values of 5.5 and 8.0 microM, respectively.
MATERIALS