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Olefin Metathesis

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Ring-opening metathesis is driven by the is driven by the force to relieve ring strain. In absence of excess of a second reaction partner, polymerization occurs (ROMP).
Cross metathesis brings two olefins together in an intermolecular reaction to give an olefin product bearing substituent from each of the starting olefins.
Ring-closing metathesis is an intramolecular reaction of an acyclic diene to form a ring.

We are committed to helping you reach new frontiers through an ever-expanding, always innovative portfolio of products for olefin metathesis. In line with this goal, we have partnered with Umicore PMC to bring you an outstanding range of olefin metathesis catalysts for chemical synthesis. Our exclusive collaboration not only gives you direct access to Umicore’s Grubbs Catalyst® technology, but also their development expertise. You’ll enjoy rapid, reliable supply of milligram to multi-kilogram volumes, at the best value, with Umicore license rights included. Moreover, you’ll benefit from dedicated technical guidance, supported by Nobel Laureate Robert Grubbs.

Related Product Literature

Olefin Metathesis Reaction Planning and Troubleshooting

Ring closing metathesis (RCM) has evolved into one of those coveted “predictable” reactions in organic synthesis.

Ruthenium Catalysts Overview

As the use of metathesis catalysts has become more prevalent in industry, understanding the decomposition pathway is crucial

Selected Best Metathesis Practices

  • Consider Concentration: Run cross-metathesis reactions concentrated and macrocyclization reactions diluted.
  • Oust Oxygen: Degassing reactions with an inert gas prior to adding a Grubbs catalyst can improve catalyst lifetime and efficiency. Degassing during the reaction has the added benefit of efficiently removing ethylene from metathesis reactions where it is generated.
  • Solvent Selection: Consider solubility and use non-coordinating solvents when possible, such as cyclohexane, toluene, or dichloromethane.
  • For more suggestions on metathesis reaction planning and troubleshooting, view the Metathesis Application Guide

Easy Access to Grubbs Catalyst® Technology

Enjoy unparalleled access to Grubbs Catalyst® technology, and experience the many benefits of our exclusive partnership.

  • Secure supply chain of metathesis catalysts from milligram to multi-kilogram volumes
  • Rapid delivery of R&D quantities
  • Access to technical expertise, supported by Nobel Laureate Robert Grubbs
  • Umicore license rights included in listed product price
Related Product Categories
Transition Metal Catalysts
Increase the rate of your reactions with our unparalleled portfolio of transition metal catalysts for your organic and organometallic chemistry breakthroughs.
Related Applications
Metathesis
Olefin metathesis involves an organic reaction that redistributes fragments of alkenes (olefins) by cleavage and transformation of carbon-carbon double bonds.
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Highlights

Aldrichimica Acta review on second-generation metathesis catalysts

Aldrichimica Acta review on ROM polymerization in facilitated synthesis

Aldrichimica Acta review on CM of nitrogen-containing systems

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