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Cross-Coupling Catalysts

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Buchwald-Hartwig cross-coupling reaction scheme for C-N or C-O bond formation
Heck cross-coupling reaction scheme for C-C bond formation
Sonogahira cross-coupling reaction scheme for C-C bond formation
Stille cross-coupling reaction scheme for C-C bond formation
Stille cross-coupling reaction scheme for C-C bond formation
Suzuki-Miyaura Cross-Coupling Reaction

Cross-coupling is a cornerstone set of reactions for the formation of carbon–carbon and carbon-heteroatom bonds. Numerous research groups have developed new metal complexes and ligands, expanding the scope of these transformations to give access to more complex molecules. Among these important reactions, several stand out, such as Suzuki-Miyaura, Negishi, Heck, Kumada, Stille, Sonogashira and Buchwald­ Hartwig amination reactions. Furthermore, scientists have developed new complexes that are able to catalyze these reactions, with high yields and low catalyst loadings. Several of the technologies developed enable these reactions to be carried out under mild reaction conditions, with high activity and high turnover numbers. Several of these catalysts have transitioned into industry successfully, catalyzing cross-coupling reactions on a ton scale.

We are dedicated to supporting all of your needs with a comprehensive cross-coupling catalysts portfolio:

Nickel Catalysts

We are pleased to offer an extensive and high-purity selection of Ni catalysts. These nickel catalysts span a range of oxidation states: Nickel (0), nickel (II), nickel (III) and nickel (IV). The types of Ni catalysts available for immediate purchase are aluminum nickel (Al Ni) alloys, ammonium nickel hydrates, Ni COD, Ni halides (chlorides, bromides, fluorides and iodides), Ni cyclopentadienyls, nickel metal, nickel acacs, and Raney Nickel catalysts.

Palladium Catalysts

The palladium catalyst is extremely versatile due to the ability to fine-tune the reaction conditions (temperature, solvents, ligands, bases, and other additives). Furthermore, palladium catalysts have a very high tolerance of various functional groups and often provide excellent stereo- and regiospecificity, which avoids the need for protecting groups. We offer an extensive portfolio of homogeneous and heterogeneous palladium catalysts.

Related Product Literature
Cross-Coupling Reaction Guide
The guide is designed to be your go-to reference for planning and setting up cross-coupling reactions. Each reaction page contains the best initial set of reaction conditions and catalyst system, which are based on the most robust and broadly applicable methods in the literature.
Related Product Categories
Phosphine Ligands
Our diverse portfolio of phosphine ligands includes monodentate, bidentate, chiral ligands, Buchwald, cataCXium®, and Dalphos ligands for applications such as Negishi, Suzuki, Stille, Heck, Sonogashira, and Buchwald-Hartwig cross-coupling.
Buchwald Catalysts & Ligands
Buchwald Catalysts and Ligands are highly active and versatile palladium precatalysts and biarylphosphine ligands used in cross-coupling reactions for the formation of C-C, C–N, C–O, C–F, C–CF3, and C–S bonds.
Boronic Acids & Derivatives
We are pleased to provide a wide range of boronic acids & derivatives, including boronate esters, trifluoroborate salts, and MIDA boronate esters. All of our boronic acid derivatives are offered as alkyl, alkenyl, aryl and heteroaryl derivatives.
Organozinc Reagents
We offer a diverse range of organozinc reagents for the formation of known bond formations and the development of new technologies in organic synthesis.
Organotin Reagents
Our offering organotin reagents and compounds are useful in the formation of known bond formations and the development of new technologies in organic synthesis.
Organoaluminum Reagents
Explore our organoaluminum reagents to enable your cross-coupling reactions and facilitate the discovery of new bond-forming methodologies.
Organosilicon Reagents
Our unprecedented portfolio of organosilicon reagents includes disilanes, silanols, silazanes, silicates, siloxanes, trialkoxysilanes to support all of your breakthrough ideas.
Organolithium Reagents
Our organolithium reagents are critical to the successful formation of known bond formations (e.g. nucleophilic addition and substitution) and the development of new technologies in organic synthesis.
Related Applications
Cross-Coupling
Cross-coupling is a common reaction in organic chemistry for the creation of C-C, C-N, and C-O bonds with the aid of a metal catalyst.
C–H Functionalization
C–H functionalization is the reliable and predictable conversion of a C–H into a C–C, C–N, C–O, or C–X bond in a selective and controlled fashion.
Fluorination
Fluorination is the introduction of fluorine to a compound via electrophilic fluorination, nucleophilic fluorination, difluoromethylation, trifluoromethylation, or perfluoroalkylation.
Metathesis
Olefin metathesis involves an organic reaction that redistributes fragments of alkenes (olefins) by cleavage and transformation of carbon-carbon double bonds.
Organic Reaction Toolbox
An organic reaction toolbox provides structure-activity relationships for unique chemical reactions to optimally design and control small molecule synthesis.
Photocatalysis
Photoredox catalysis utilizes photocatalysts in the presence of visible light to form an array of synthetic transformations including, but not limited to, cross-coupling, C-H functionalization, alkene and arene functionalization, and trifluoromethylation.
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