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Key Documents

B3383

Sigma-Aldrich

Benzidine dihydrochloride

≥99% (titration)

Synonym(s):

4,4′-Diaminobiphenyl dihydrochloride

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About This Item

Empirical Formula (Hill Notation):
C12H12N2 · 2HCl
CAS Number:
Molecular Weight:
257.16
Beilstein:
3914846
EC Number:
MDL number:
UNSPSC Code:
12352116
PubChem Substance ID:
NACRES:
NA.25

Quality Level

Assay

≥99% (titration)

form

powder

SMILES string

Cl[H].Cl[H].Nc1ccc(cc1)-c2ccc(N)cc2

InChI

1S/C12H12N2.2ClH/c13-11-5-1-9(2-6-11)10-3-7-12(14)8-4-10;;/h1-8H,13-14H2;2*1H

InChI key

RUAXWVDEYJEWRY-UHFFFAOYSA-N

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Application

Benzidine (4,4′-Diaminobiphenyl) is an environmental genotoxin that posses increased risks of cancer to exposed people. Benzidine may be used as a reference material in procedures that analyze for benzidine. Benzidine can be used in studies on its mechanisms of genotoxicity.

Biochem/physiol Actions

Tumor initiator in mammary glands of experimental animal.

Warning

Cancer suspect agent.

Signal Word

Danger

Hazard Statements

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 1A

Storage Class Code

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

EU REACH Annex XVII (Restriction List)

CAS No.

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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K C Morton et al.
Carcinogenesis, 2(8), 747-752 (1981-01-01)
To evaluate the role of metabolism in benzidine (BZ) carcinogenesis, BZ and 2 or its metabolites, N,N'-diacetylbenzidine and N-hydroxy-N,N'-diacetylbenzidine (NOHDABZ), were given by i.p. injection to female CD rats twice weekly for 4 weeks beginning at 30 days of age.
Yan Cao et al.
Stem cells and development, 24(22), 2660-2673 (2015-07-17)
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Journal of the American Chemical Society, 132(37), 13016-13025 (2010-08-31)
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Lu Zhu et al.
Optics letters, 36(10), 1821-1823 (2011-05-20)
We have fabricated an organic deep ultraviolet photodetector (PD) using PEDOT:PSS (PH 1000) as a transparent anode. NPB and PBD were employed as electron donor and acceptor, respectively. The PD exhibits a dark current of 0.0829 μA/cm(2) and a photocurrent
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American journal of industrial medicine, 52(8), 625-632 (2009-06-30)
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