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Merck

HLA-B

major histocompatibility complex, class I, B

Synonyms:
AS, HLAB, SPDA1
Species:
Human HLA-B (3106)
UniProtKB ID:
P30464, B0V0B8, P30465, P30513, Q29633, Q29636, Q29829, Q29953
Gene ID:
  • Human(3106) Summary: HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described. [provided by RefSeq, Jul 2008]

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Antibodies

Product Number
Description
Species Reactivity
Application
MAB1285
Anti-HLA-B27 Antibody, clone HLA.ABC.m3, clone HLA.ABC.m3, Chemicon®, from mouse,
Species Reactivity
human
Application
flow cytometry
immunocytochemistry
SAB1405937
Anti-HLA-B antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
western blot
ZRB2779
Anti-HLA-B Antibody, clone 1L21 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Species Reactivity
human
Application
affinity binding assay
flow cytometry
immunofluorescence
immunohistochemistry
western blot
SAB1410631
Anti-HLA-B antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
western blot
MAB1288
Anti-HLA-B7 Antibody, clone BB7.1, PE Conjugate, clone BB7.1, Chemicon®, from mouse,
Species Reactivity
human
Application
flow cytometry