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Merck

GABBR2

gamma-aminobutyric acid (GABA) B receptor, 2

Synonyms:
GABABR2, GPR51, GPRC3B, HG20, HRIHFB2099
Species:
UniProtKB ID:
Gene ID:
  • Human(9568) Summary: The multi-pass membrane protein encoded by this gene belongs to the G-protein coupled receptor 3 family and GABA-B receptor subfamily. The GABA-B receptors inhibit neuronal activity through G protein-coupled second-messenger systems, which regulate the release of neurotransmitters, and the activity of ion channels and adenylyl cyclase. This receptor subunit forms an active heterodimeric complex with GABA-B receptor subunit 1, neither of which is effective on its own. Allelic variants of this gene have been associated with nicotine dependence.[provided by RefSeq, Jan 2010]
  • Mouse(242425) gamma-aminobutyric acid (GABA) B receptor, 2
  • Rat(83633) gamma-aminobutyric acid (GABA) B receptor 2
  • Zebrafish(560267) gamma-aminobutyric acid (GABA) B receptor, 2
  • dog(481627) gamma-aminobutyric acid (GABA) B receptor, 2
  • Horse(100063963) gamma-aminobutyric acid (GABA) B receptor, 2
  • cow(517040) gamma-aminobutyric acid (GABA) B receptor, 2
  • domestic cat(101093058) gamma-aminobutyric acid (GABA) B receptor, 2
  • chicken(420979) gamma-aminobutyric acid (GABA) B receptor, 2
  • domestic guinea pig(100170764) gamma-aminobutyric acid (GABA) B receptor, 2
  • naked mole-rat(101719923) gamma-aminobutyric acid (GABA) B receptor, 2
  • sheep(101103544) gamma-aminobutyric acid (GABA) B receptor, 2
  • Domestic Rabbit(100346845) gamma-aminobutyric acid (GABA) B receptor, 2

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Small Molecule - Agonist

Product Number
Description
Species
Baclofen, British Pharmacopoeia (BP) Reference Standard,
Species
human
Baclofen, European Pharmacopoeia (EP) Reference Standard,
Species
human
Baclofen, United States Pharmacopeia (USP) Reference Standard,
Species
human
Baclofen, Pharmaceutical Secondary Standard; Certified Reference Material,
Species
human
Baclofen solution, 500 μg/mL (90:10 MeOH:DMSO), certified reference material, ampule of 1 mL, Cerilliant®,
Species
human

Small Molecule - Allosteric Modulator

Product Number
Description
Species
CGP-13501, ≥98% (HPLC), solid,
Species
human

Small Molecule - Antagonist

Product Number
Description
Species
2-Hydroxysaclofen, ≥98% (TLC), solid,
Species
human
Phaclofen, solid,
Species
human
(±)-Baclofen, ≥98% (HPLC), solid,
Species
human, rat
Saclofen, solid,
Species
mouse, human, rat
γ-Aminobutyric acid, ≥99%,
Species
human, rat

Antibodies

Product Number
Description
Species Reactivity
Application
Monoclonal Anti-Gaba-B Receptor 2 - Atto 488 antibody produced in mouse, clone S81-2, purified immunoglobulin,
Species Reactivity
human, mouse, rat
Application
immunocytochemistry
immunohistochemistry

western blot
Monoclonal Anti-Gaba-B Receptor 2 - Biotin antibody produced in mouse, clone S81-2, purified immunoglobulin,
Species Reactivity
human, mouse, rat
Application
immunocytochemistry
immunohistochemistry

western blot
Monoclonal Anti-Gaba-B Receptor 2 - Hrp antibody produced in mouse, clone S81-2, purified immunoglobulin,
Species Reactivity
human, mouse, rat
Application
immunocytochemistry
immunohistochemistry

western blot
Monoclonal Anti-Gaba-B Receptor 2 - Rpe antibody produced in mouse, clone S81-2, purified immunoglobulin,
Species Reactivity
human, mouse, rat
Application
immunocytochemistry
immunohistochemistry

western blot
Anti-GABAB Receptor 2 antibody produced in rabbit, affinity isolated antibody, lyophilized powder,
Species Reactivity
rat
Application
western blot

Small Molecule - Inhibitor

Product Number
Description
Species
NO-711 hydrochloride, ≥98% (HPLC),
Species
human
(±)-Vigabatrin, ,
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human GABBR2,
Species
human