- Enhancing KCC2 function counteracts morphine-induced hyperalgesia.
Enhancing KCC2 function counteracts morphine-induced hyperalgesia.
Scientific reports (2017-06-22)
Francesco Ferrini, Louis-Etienne Lorenzo, Antoine G Godin, Miorie Le Quang, Yves De Koninck
PMID28634406
ABSTRACT
Morphine-induced hyperalgesia (MIH) is a severe adverse effect accompanying repeated morphine treatment, causing a paradoxical decrease in nociceptive threshold. Previous reports associated MIH with a decreased expression of the Cl