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  • Early response of the human SOST gene to stimulation by 1α,25-dihydroxyvitamin D

Early response of the human SOST gene to stimulation by 1α,25-dihydroxyvitamin D

The Journal of steroid biochemistry and molecular biology (2015-12-23)
Asiri R Wijenayaka, Matthew Prideaux, Dongqing Yang, Howard A Morris, David M Findlay, Paul H Anderson, Gerald J Atkins
PMID26690786
ABSTRACT

The osteocyte expressed gene SOST encodes sclerostin, a potent negative regulator of bone formation and inducer of bone resorption. We have recently demonstrated that the human SOST gene is positively regulated in response to 1α,25-dihydroxyvitamin D