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SMARCA5 methylation and expression in gastric cancer.

Cancer investigation (2011-01-26)
Carolina Oliveira Gigek, Luara Carolina Frias Lisboa, Mariana Ferreira Leal, Patricia Natalia Oliveira Silva, Eleonidas Moura Lima, André Salim Khayat, Paulo Pimentel Assumpção, Rommel Rodriguez Burbano, Marilia de Arruda Cardoso Smith
PMID21261476
ABSTRACT

Here, we first evaluated SMARCA5 expression and promoter DNA methylation in gastric carcinogenesis. Immunohistochemistry and methylation-specific PCR were analyzed in 19 and 48 normal mucosa and in 52 and 92 gastric cancer samples, respectively. We observed higher immunoreactivity of SMARCA5 in gastric cancer samples than in normal mucosa. Moreover, SMARCA5 promoter methylation was associated with the absence of protein expression. Our findings suggest that SMARCA5 has a potential role in proliferation and malignancy in gastric carcinogenesis.