G013

R(+)-Baclofen hydrochloride

solid

• Synonym(s): Arbaclofen hydrochloride, R(+)-β-(Aminomethyl)-4-chlorobenzenepropanoic acid hydrochloride, STX209
• Empirical Formula (Hill Notation): C₁₀H₁₂ClNO₂ · HCl
• CAS Number: 63701-55-3
• Molecular Weight: 250.12
• MDL number: MFCD00078579
• UNSPSC Code: 12352200
• PubChem Substance ID: 24895006
• NACRES: NA.32

Properties

• form: solid
• Quality Level: 100
• optical activity: [α]28/D +3.8°, c = 0.9 in methanol(lit.)
• storage condition: desiccated
• color: white
• solubility: DMSO: >20 mg/mL; H₂O: 26 mg/mL (Solutions may be stored for several weeks at 4 °C.)
• SMILES string: Cl[H].NC[C@H](CC(O)=O)c1ccc(Cl)cc1
• InChI: 1S/C10H12ClNO2.ClH/c11-9-3-1-7(2-4-9)8(6-12)5-10(13)14;/h1-4,8H,5-6,12H2,(H,13,14);1H/t8-;/m0./s1
• InChI key: WMNUVYYLMCMHLU-QRPNPIFTSA-N
• Gene Information: human ... GABBR1(2550) ; mouse ... GABBR1(54393) ; rat ... GABBR1(81657)

Description

Application

R(+)-Baclofen hydrochloride has been used as a GABA_B receptor agonist to study its effects on M43068-induced antinociception in rat models. It has also been used as a GABA_B receptor agonist to study its effects on amphetamine-induced behavior and neurochemical responses in rat striatum.

Biochem/physiol Actions

Baclofen is a derivative of γ-aminobutyric acid (GABA) and acts as a 4-aminobutanoic acid receptor (GABA_B) agonist. It interacts stereospecifically with the GABA receptor and exhibits antispastic effects.Baclofen shows therapeutic effects against paroxysmal pain of trigeminal neuralgia and spinal spasticity. R(+)-Baclofen is a more active enantiomer.

Other Notes

Same enantiomer as R(−)-baclofen free base.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves