8.08913

Zirconium(IV) chloride

anhydrous, for synthesis

• Synonym(s): Zirconium(IV) chloride, Zirconium tetrachloride
• Empirical Formula (Hill Notation): Cl₄Zr
• CAS Number: 10026-11-6
• Molecular Weight: 233.04
• MDL number: MFCD00011306
• UNSPSC Code: 12352302
• EC Index Number: 233-058-2
• NACRES: NA.22

Properties

• vapor pressure: 1.3 hPa ( 190 °C)
• Quality Level: 200
• form: crystals
• potency: 1688 mg/kg LD₅₀, oral (Rat)
• pH: <1 (20 °C in H₂O, saturated aqueous solution)
• mp: 437 °C
• density: 2.80 g/cm³ at 15 °C
• bulk density: 1200 kg/m³
• storage temp.: 2-30°C
• InChI: 1S/4ClH.Zr/h4*1H;/q;;;;+4/p-4
• InChI key: DUNKXUFBGCUVQW-UHFFFAOYSA-J

Description

General description

Zirconium(IV) chloride is a Lewis acid catalyst, widely used in organic synthesis for the preparation of useful key intermediates. Since it is a stable and environmentally friendly catalyst used in various chemical reactions such as carbon-carbon bond formation reactions, reduction reactions, protection, and deprotection reactions.

Application

Zirconium(IV) chloride can be used as a catalyst to synthesize:

• β-amino alcohols by ring-opening of epoxides with aromatic amines.
• β-amino analogs via conjugate addition of aliphatic amines to α,β-unsaturated ester, nitriles, and ketones.
• 1,3,4-oxadiazole derivatives by cyclodehydration of 1,2-diacylhydrazines.
• 3,4-Dihydropyrimidinone derivatives via Biginelli condensation reaction of aromatic aldehyde, β-ketoester, and urea.

Analysis Note

Assay (argentometric): ≥ 98.0 %
Hafnium (Hf): ≤ 40 ppm
Identity (ICP-OES): passes test

Safety Information

• Pictograms: GHS05
• Signal Word: Danger
• Hazard Statements: H290 - H314
• Precautionary Statements: P234 - P260 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Hazard Classifications: Met. Corr. 1 - Skin Corr. 1B
• Supplementary Hazards: EUH014 - EUH071
• Storage Class Code: 8B - Non-combustible, corrosive hazardous materials
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable