05-23-3801
Endothelin 3, Human and Rat
Attenuates thrombin-evoked aggregation of human platelets.
Synonym(s):
Endothelin 3, Human and Rat, ET-3, CTCFTYKDKECVYYCHLDIIW
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About This Item
Empirical Formula (Hill Notation):
C121H168N26O33S4
CAS Number:
Molecular Weight:
2643.04
MDL number:
UNSPSC Code:
12352202
NACRES:
NA.77
Recommended Products
Quality Level
Assay
≥97% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
desiccated
solubility
5% acetic acid: 0.5 mg/mL
shipped in
ambient
storage temp.
−20°C
General description
Attenuates thrombin-evoked aggregation of human platelets. A potent stimulator of interleukin-6 production by endothelial cell lines. Reported to activate phopholipase C in fibroblasts expressing ETA receptors.
Attenuates thrombin-evoked aggregation of human platelets. A potent stimulator of interleukin-6 production by endothelial cell lines. Reported to activate phospholipase C in fibroblasts expressing ETA receptors.
Biochem/physiol Actions
Cell permeable: no
Primary Target
Stimulator of interleukin-6 production by endothelial cell lines
Stimulator of interleukin-6 production by endothelial cell lines
Product does not compete with ATP.
Reversible: no
Packaging
Yes
Sequence
H-Cys¹-Thr-Cys³-Phe-Thr-Tyr-Lys-Asp-Lys-Glu-Cys¹¹-Val-Tyr-Tyr-Cys¹⁵-His-Leu-Asp-Ile-Ile-Trp-OH (disulfide bonds: 1 → 15; 3 → 11)
Physical form
Supplied as a trifluoroacetate salt. Sold on the basis of peptide content.
Preparation Note
Dissolve peptide initially at 8 mg/ml in 80% cold acetic acid, then dilute with cold water to 5% acetic acid and 0.5 mg/ml peptide.
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Other Notes
Gresser, O., et al. 1996. Biochem. Biophys. Res. Commun.224, 169.
Astarie-Dequeker, C., et al. 1995. Br. J. Pharmacol. 114, 524.
Xin, X., et al. 1995. Endocrinology 136, 132.
Brunner, F., et al. 1992. J. Mol. Cell. Cardiol.24, 1291.
Lamers, J.M., et al. 1992. Mol. Cell. Biochem. 116, 59.
Astarie-Dequeker, C., et al. 1995. Br. J. Pharmacol. 114, 524.
Xin, X., et al. 1995. Endocrinology 136, 132.
Brunner, F., et al. 1992. J. Mol. Cell. Cardiol.24, 1291.
Lamers, J.M., et al. 1992. Mol. Cell. Biochem. 116, 59.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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