N-079
(R,S)-Norcotinine solution
1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®
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About This Item
Empirical Formula (Hill Notation):
C9H10N2O
CAS Number:
Molecular Weight:
162.19
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
Recommended Products
grade
certified reference material
Quality Level
feature
(Snap-N-Spike®)
packaging
ampule of 1 mL
manufacturer/tradename
Cerilliant®
concentration
1.0 mg/mL in methanol
format
single component solution
storage temp.
−20°C
SMILES string
O=C1NC(C2=CN=CC=C2)CC1
InChI
1S/C9H10N2O/c12-9-4-3-8(11-9)7-2-1-5-10-6-7/h1-2,5-6,8H,3-4H2,(H,11,12)
InChI key
FXFANIORDKRCCA-UHFFFAOYSA-N
General description
Norcotinine, or desmethylcotinine, is a urinary metabolite of nornicotine and cotinine found in smokers and users of other nicotine products including chewing tobacco and snuff. This Certified Spiking Solution® is suitable for use in nicotine testing methods or clinical and diagnostic testing of nicotine biomarkers by LC-MS/MS or GC/MS.
Legal Information
CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany
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Description
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Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
Target Organs
Eyes
Storage Class Code
3 - Flammable liquids
WGK
WGK 1
Flash Point(F)
49.5 °F
Flash Point(C)
9.7 °C
Certificates of Analysis (COA)
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N Eldirdiri et al.
European journal of drug metabolism and pharmacokinetics, 22(4), 385-390 (1998-03-26)
Since norcotinine and 4-(3-pyridyl)-4-oxobutyramide (POBAM) are probable metabolites of nicotine and cotinine, it was of interest to investigate the further in vitro metabolism of these compounds. We now report our preliminary findings using rat microsomal preparations (induced and/or non-induced with
P A Crooks et al.
Drug metabolism and disposition: the biological fate of chemicals, 25(1), 47-54 (1997-01-01)
The time course of nicotine metabolite appearance in brain from 5 min-18 hr after subcutaneous administration of S-(-)-[3H-N-methyl]nicotine was determined. Results demonstrated that metabolite appearance in brain was greatest at 4 hr postadministration, whereas levels of nicotine were greatly diminished
Diaa M Shakleya et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 877(29), 3537-3542 (2009-09-15)
An LC-MS/MS method for the simultaneous quantification of nicotine, cotinine, trans-3'-hydroxycotinine and norcotinine in human plasma was developed and fully validated. Potential endogenous and exogenous interferences were extensively evaluated and limits of quantification were determined by decreasing analyte concentration. Analytical
Diaa M Shakleya et al.
Analytical and bioanalytical chemistry, 395(7), 2349-2357 (2009-10-20)
An analytical procedure was developed and validated for the simultaneous identification and quantification of nicotine, cotinine, trans-3'-hydroxycotinine, and norcotinine in 0.5 mL of human oral fluid collected with the Quantisal oral fluid collection device. Solid phase extraction and liquid chromatography-tandem
H Foth et al.
Toxicology and applied pharmacology, 105(3), 382-392 (1990-09-15)
Elimination parameters of [14C]nicotine in conscious rats receiving nicotine (0.3 mg/kg) either intravenously or orally were studied. The oral availability of unchanged nicotine, derived by comparison of the respective areas under the concentration vs time curves (AUC), was 89%, indicating
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