923338
5-((2-(tert-Butoxycarbonyl)-2-azaspiro[3.3]heptan-6-yl)oxy)pyrazine-2-carboxylic acid
Synonym(s):
Rigid linker for PROTAC® development
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About This Item
Empirical Formula (Hill Notation):
C16H21N3O5
Molecular Weight:
335.36
UNSPSC Code:
12352106
NACRES:
NA.22
form
powder or crystals
Quality Level
reaction suitability
reagent type: linker
functional group
Boc
carboxylic acid
storage temp.
2-8°C
SMILES string
OC(C1=NC=C(OC2CC3(C2)CN(C(OC(C)(C)C)=O)C3)N=C1)=O
Application
5-((2-(tert-Butoxycarbonyl)-2-azaspiro[3.3]heptan-6-yl)oxy)pyrazine-2-carboxylic acid is useful as a rigid linker in PROTAC development for targeted protein degradation as well as chemical conjugates. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties. Developed in partnership with ComInnex.
Similar linkers in this series:
923311
923370
923419
923346
923427
Similar linkers in this series:
923311
923370
923419
923346
923427
Other Notes
Legal Information
PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
related product
Product No.
Description
Pricing
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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