TNNT3
troponin T type 3 (skeletal, fast)
Synonyms:
TNTF
Species:
Human TNNT3 (7140), Mouse Tnnt3 (21957), Rat Tnnt3 (24838), chicken TNNT3 (395761), dog TNNT3 (475996), domestic cat TNNT3 (101091149), cow TNNT3 (282096), sheep TNNT3 (101104467), Goat TNNT3 (100861247), domestic guinea pig Tnnt3 (100734707) ...More
UniProtKB ID:
Gene ID:
- Human(7140) Summary: The binding of Ca(2+) to the trimeric troponin complex initiates the process of muscle contraction. Increased Ca(2+) concentrations produce a conformational change in the troponin complex that is transmitted to tropomyosin dimers situated along actin filaments. The altered conformation permits increased interaction between a myosin head and an actin filament which, ultimately, produces a muscle contraction. The troponin complex has protein subunits C, I, and T. Subunit C binds Ca(2+) and subunit I binds to actin and inhibits actin-myosin interaction. Subunit T binds the troponin complex to the tropomyosin complex and is also required for Ca(2+)-mediated activation of actomyosin ATPase activity. There are 3 different troponin T genes that encode tissue-specific isoforms of subunit T for fast skeletal-, slow skeletal-, and cardiac-muscle. This gene encodes fast skeletal troponin T protein; also known as troponin T type 3. Alternative splicing results in multiple transcript variants encoding additional distinct troponin T type 3 isoforms. A developmentally regulated switch between fetal/neonatal and adult troponin T type 3 isoforms occurs. Additional splice variants have been described but their biological validity has not been established. Mutations in this gene may cause distal arthrogryposis multiplex congenita type 2B (DA2B). [provided by RefSeq, Oct 2009]
- Mouse(21957) troponin T3, skeletal, fast
- Rat(24838) troponin T type 3 (skeletal, fast)
- chicken(395761) troponin T type 3 (skeletal, fast)
- dog(475996) troponin T type 3 (skeletal, fast)
- domestic cat(101091149) troponin T type 3 (skeletal, fast)
- cow(282096) troponin T type 3 (skeletal, fast)
- sheep(101104467) troponin T type 3 (skeletal, fast)
- Goat(100861247) troponin T type 3 (skeletal, fast)
- domestic guinea pig(100734707) troponin T type 3 (skeletal, fast)
- Domestic Rabbit(100009527) troponin T type 3 (skeletal, fast)
- naked mole-rat(101718573) troponin T type 3 (skeletal, fast)
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-TNNT3 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
western blot
western blot
Anti-TNNT3 antibody produced in rabbit, IgG fraction of antiserum,
Species Reactivity
bovine, dog, goat, guinea pig, horse, human, mouse, rabbit, rat
Application
western blot
Anti-TNNT3 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
Monoclonal Anti-TNNT3, (C-terminal) antibody produced in mouse, clone 1H4, ascites fluid,
Species Reactivity
human, rat
Application
ELISA
western blot
western blot
Monoclonal Anti-Troponin T antibody produced in mouse, clone JLT-12, ascites fluid,
Species Reactivity
bovine, chicken, rabbit, rat
Application
immunohistochemistry
western blot
western blot
esiRNA
Product Number
Description
Species