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Merck

TNFRSF10B

tumor necrosis factor receptor superfamily, member 10b

Synonyms:
CD262, DR5, KILLER, KILLER/DR5, TRAIL-R2, TRAILR2, TRICK2, TRICK2A, TRICK2B, TRICKB, ZTNFR9
Species:
UniProtKB ID:
Gene ID:
  • Human(8795) Summary: The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene. [provided by RefSeq, Mar 2009]
  • Mouse(21933) tumor necrosis factor receptor superfamily, member 10b
  • Rat(364420) tumor necrosis factor receptor superfamily, member 10b
  • chicken(373904) tumor necrosis factor receptor superfamily, member 10b
  • naked mole-rat(101697353) tumor necrosis factor receptor superfamily, member 10b
  • cow(282533) tumor necrosis factor receptor superfamily, member 10b
  • cow(784541) tumor necrosis factor receptor superfamily, member 10b

Custom & Knockdown Gene Products

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ELISA

Product Number
Description
Species
Human TRAIL R2 ELISA Kit, for serum, plasma and cell culture supernatants,
Species
human

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-DR5 antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human, mouse
Application
ELISA
immunocytochemistry

western blot
Anti-TNFRSF10B antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
western blot
Monoclonal Anti-CD262-APC antibody produced in mouse, clone DR5-01-1,
Species Reactivity
Application
flow cytometry
Monoclonal Anti-TNFRSF10B antibody produced in mouse, clone 2D6, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunoprecipitation (IP)

western blot
Anti-TNFRSF10B antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
western blot

Proteins

Product Number
Description
Species
sTRAIL Receptor-2 (DR5) human, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture,
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting mouse Tnfrsf10b,
Species
mouse
MISSION® esiRNA, targeting human TNFRSF10B,
Species
human