PRKCI
protein kinase C, iota
Synonyms:
DXS1179E, PKCI, nPKC-iota
Species:
Human PRKCI (5584), Mouse Prkci (18759), Rat Prkci (84006), Zebrafish prkci (117507), dog PRKCI (478686), domestic cat PRKCI (101087000), Horse PRKCI (100063737), chicken PRKCI (424991), cow PRKCI (528478), sheep PRKCI (101118322) ...More
UniProtKB ID:
Gene ID:
- Human(5584) Summary: This gene encodes a member of the protein kinase C (PKC) family of serine/threonine protein kinases. The PKC family comprises at least eight members, which are differentially expressed and are involved in a wide variety of cellular processes. This protein kinase is calcium-independent and phospholipid-dependent. It is not activated by phorbolesters or diacylglycerol. This kinase can be recruited to vesicle tubular clusters (VTCs) by direct interaction with the small GTPase RAB2, where this kinase phosphorylates glyceraldehyde-3-phosphate dehydrogenase (GAPD/GAPDH) and plays a role in microtubule dynamics in the early secretory pathway. This kinase is found to be necessary for BCL-ABL-mediated resistance to drug-induced apoptosis and therefore protects leukemia cells against drug-induced apoptosis. There is a single exon pseudogene mapped on chromosome X. [provided by RefSeq, Jul 2008]
- Mouse(18759) protein kinase C, iota
- Rat(84006) protein kinase C, iota
- Zebrafish(117507) protein kinase C, iota
- dog(478686) protein kinase C, iota
- domestic cat(101087000) protein kinase C, iota
- Horse(100063737) protein kinase C, iota
- chicken(424991) protein kinase C, iota
- cow(528478) protein kinase C, iota
- sheep(101118322) protein kinase C, iota
- domestic guinea pig(100731983) protein kinase C, iota
- naked mole-rat(101697279) protein kinase C, iota
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Small Molecule - Agonist
Product Number
Description
Species
Antibodies
Product Number
Description
Species Reactivity
Application
Monoclonal Anti-PRKCI antibody produced in mouse, clone 1G11, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunofluorescence
western blot
immunofluorescence
western blot
ANTI-PKC IOTA(N-TERMINAL) antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution,
Species Reactivity
human
Application
immunohistochemistry
western blot
western blot
ANTI-PRKCI antibody produced in mouse, clone 1C10, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
western blot
western blot
Anti-PRKCI antibody produced in rabbit, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-PRKCI antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Species Reactivity
human
Application
immunofluorescence
Small Molecule - Inhibitor
Proteins
Product Number
Description
Species
PKC iota Recombinant Human Protein, Active, 10 µg, Active, N-terminal His6-tagged, recombinant full-length human PKC iota. For use in Kinase Assays.,
Species
human
PKCι, active, GST tagged human, PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Species
human