LIMK1
LIM domain kinase 1
Synonyms:
LIMK, LIMK-1
Species:
Human LIMK1 (3984), Mouse Limk1 (16885), Rat Limk1 (65172), fruit fly LIMK1 (32207), cow LIMK1 (535225), Horse LIMK1 (100062100), domestic cat LIMK1 (101097861), chicken LIMK1 (373922), dog LIMK1 (489800), domestic guinea pig Limk1 (100712921) ...More
UniProtKB ID:
Gene ID:
- Human(3984) Summary: There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is a serine/threonine kinase that regulates actin polymerization via phosphorylation and inactivation of the actin binding factor cofilin. This protein is ubiquitously expressed during development and plays a role in many cellular processes associated with cytoskeletal structure. This protein also stimulates axon growth and may play a role in brain development. LIMK1 hemizygosity is implicated in the impaired visuospatial constructive cognition of Williams syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Feb 2011]
- Mouse(16885) LIM-domain containing, protein kinase
- Rat(65172) LIM domain kinase 1
- fruit fly(32207) LIM-kinase1
- cow(535225) LIM domain kinase 1
- Horse(100062100) LIM domain kinase 1
- domestic cat(101097861) LIM domain kinase 1
- chicken(373922) LIM domain kinase 1
- dog(489800) LIM domain kinase 1
- domestic guinea pig(100712921) LIM domain kinase 1
- naked mole-rat(101698555) LIM domain kinase 1
- sheep(101110900) LIM domain kinase 1
- Domestic Rabbit(100344018) LIM domain kinase 1
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Antibodies
Product Number
Description
Species Reactivity
Application
ANTI-LIMK1 antibody produced in mouse, clone 2E9, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-phospho-LIMK1 (pThr508) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-phospho-LIMK1 (pThr508) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-LIMK1 Antibody, clone 40/00-1B11-1-1, clone 40/00-1B11-1-1, from rat,
Species Reactivity
human, mouse
Application
immunocytochemistry
immunohistochemistry
immunoprecipitation (IP)
western blot
immunohistochemistry
immunoprecipitation (IP)
western blot
Anti-phospho-LIMK 1/2 (Tyr507/Thr508) Antibody, Upstate®, from rabbit,
Species Reactivity
human
Application
western blot
Proteins
Product Number
Description
Species
LIM Kinase 1 Protein, active, 10 µg, Active, N-terminal 6His-tagged, recombinant, human LIM Kinase 1, amino acids 285-638, for use in Kinase Assays.,
Species
human
LIM Kinase 1 Protein, inactive, 50 g, Unactive, N-terminal 6His-tagged, recombinant, human LIM Kinase 1, amino acids 285-638. For use in Kinase Assays.,
Species
human
esiRNA
Product Number
Description
Species