LATS1
large tumor suppressor kinase 1
Synonyms:
WARTS, wts
Species:
Human LATS1 (9113), Mouse Lats1 (16798), Rat Lats1 (308265), sheep LATS1 (101122867), Domestic Rabbit LATS1 (100341222), domestic guinea pig Lats1 (100716806), naked mole-rat Lats1 (101725200), Zebrafish lats1 (553164), chicken LATS1 (421627), cow LATS1 (535935) ...More
UniProtKB ID:
Gene ID:
- Human(9113) Summary: The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments. Two protein-coding transcripts and one non-protein coding transcript have been found for this gene. [provided by RefSeq, Jul 2012]
- Mouse(16798) large tumor suppressor
- Rat(308265) large tumor suppressor kinase 1
- sheep(101122867) LATS, large tumor suppressor, homolog 1 (Drosophila)
- Domestic Rabbit(100341222) LATS, large tumor suppressor, homolog 1 (Drosophila)
- domestic guinea pig(100716806) large tumor suppressor kinase 1
- naked mole-rat(101725200) large tumor suppressor kinase 1
- Zebrafish(553164) LATS, large tumor suppressor, homolog 1 (Drosophila)
- chicken(421627) LATS, large tumor suppressor, homolog 1 (Drosophila)
- cow(535935) LATS, large tumor suppressor, homolog 1 (Drosophila)
- Horse(100060397) LATS, large tumor suppressor, homolog 1 (Drosophila)
- domestic cat(101081470) LATS, large tumor suppressor, homolog 1 (Drosophila)
- dog(476241) LATS, large tumor suppressor, homolog 1 (Drosophila)
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-p-LATS1 (Thr1079) Antibody, clone 2D2 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Species Reactivity
human, mouse, rat
Application
immunocytochemistry
inhibition assay
western blot
inhibition assay
western blot
Anti-LATS1 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse
Application
ELISA
immunohistochemistry
immunohistochemistry
Anti-LATS1 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
bovine, dog, horse, human, mouse, rabbit, rat, sheep
Application
western blot
Monoclonal Anti-LATS1 antibody produced in mouse, clone 3A7, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
western blot
western blot
Anti-LATS1 (N-term) antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution,
Species Reactivity
human, mouse, rat
Application
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Proteins
Product Number
Description
Species
LATS1, active, GST tagged human, PRECISIO®, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Species
human
esiRNA
Product Number
Description
Species