- Activation of Dopamine D1-D2 Receptor Complex Attenuates Cocaine Reward and Reinstatement of Cocaine-Seeking through Inhibition of DARPP-32, ERK, and ΔFosB.
Activation of Dopamine D1-D2 Receptor Complex Attenuates Cocaine Reward and Reinstatement of Cocaine-Seeking through Inhibition of DARPP-32, ERK, and ΔFosB.
Frontiers in pharmacology (2018-01-23)
Ahmed Hasbi, Melissa L Perreault, Maurice Y F Shen, Theresa Fan, Tuan Nguyen, Mohammed Alijaniaram, Tomek J Banasikowski, Anthony A Grace, Brian F O'Dowd, Paul J Fletcher, Susan R George
PMID29354053
RESUMEN
A significant subpopulation of neurons in rat nucleus accumbens (NAc) coexpress dopamine D1 and D2 receptors, which can form a D1-D2 receptor complex, but their relevance in addiction is not known. The existence of the D1-D2 heteromer in the striatum of rat and monkey was established using
MATERIALES
Referencia del producto
Marca
Descripción del producto
Sigma-Aldrich
Anti-D1 Dopamine Receptor antibody,Rat monoclonal, clone 1-1-F11 s.E6, purified from hybridoma cell culture
Sigma-Aldrich
Anti-phospho-ERK1 (pThr202/pTyr204) and ERK2 (pThr185/pTyr187) antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution