- Cytokine receptor signaling through the Jak-Stat-Socs pathway in disease.
Cytokine receptor signaling through the Jak-Stat-Socs pathway in disease.
Molecular immunology (2007-01-09)
Lynda A O'Sullivan, Clifford Liongue, Rowena S Lewis, Sarah E M Stephenson, Alister C Ward
PMID17208301
RESUMEN
The complexity of multicellular organisms is dependent on systems enabling cells to respond to specific stimuli. Cytokines and their receptors are one such system, whose perturbation can lead to a variety of disease states. This review represents an overview of our current understanding of the cytokine receptors, Janus kinases (Jaks), Signal transducers and activators of transcription (Stats) and Suppressors of cytokine signaling (Socs), focussing on their contribution to diseases of an immune or hematologic nature.