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[Advances in studies on pharmacokinetics of aristolochic acid I].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica (2006-12-15)
Guan Wang, Zhi-Min Wang, Qi-Shi Sun
RESUMEN

Aristolochic acid I (AA-I) was absorbed and distributed quickly in vivo, the plasma concentration-time curve were fit with the open two-compartment model and one-compartment model, respectively. The elimination of AA-I has relationship with the dosage, the low dose group eliminates more quickly than the high dose group. The characters of pharmacokinetics of AA-I induce the cumulation of AA-I in vivo and the nephrotoxin to the kidney and other viscera.

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Aristolochic acid I, powder
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Aristolochia, European Pharmacopoeia (EP) Reference Standard
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Aristolochic acid I, European Pharmacopoeia (EP) Reference Standard
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