- Substituted 5-benzyl-2-phenyl-5H-imidazo[4,5-c]pyridines: a new class of pestivirus inhibitors.
Substituted 5-benzyl-2-phenyl-5H-imidazo[4,5-c]pyridines: a new class of pestivirus inhibitors.
Bioorganic & medicinal chemistry letters (2006-08-12)
Gerhard Puerstinger, Jan Paeshuyse, Piet Herdewijn, Jef Rozenski, Erik De Clercq, Johan Neyts
PMID16901692
RESUMEN
A novel class of inhibitors of pestiviruses (5-substituted 2-phenyl-5H-imidazo[4,5-c]pyridines) is described. Modification of the substituent in position 5 resulted in analogues with high activity (EC(50)<100nM) and selectivity (SI>1000) against the pestivirus BVDV (bovine viral diarrhea virus).
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