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Merck

Borate esters as convenient reagents for direct amidation of carboxylic acids and transamidation of primary amides.

Organic & biomolecular chemistry (2011-01-08)
Pavel Starkov, Tom D Sheppard
RESUMEN

Simple borates serve as effective promoters for amide bond formation with a variety of carboxylic acids and amines. With trimethyl or tris(2,2,2-trifluoroethyl) borate, amides are obtained in good to excellent yield and high purity after a simple work-up procedure. Tris(2,2,2-trifluoroethyl) borate can also be used for the straightforward conversion of primary amides to secondary amides via transamidation.

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Sigma-Aldrich
Tris(2,2,2-trifluoroethyl) borate, 97%
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