Reversal of the effect of 17-beta-estradiol 17-beta-acetate on aminoacyl-tRNA synthetase phosphatase and aminoacyl-tRNA synthetase activities in the uterus and liver of ovariectomized Bom:NMRI mice by 2-deoxyadenosine 3-phosphate.

When an adenylyl cyclase inhibitor, 2-deoxyadenosine 3'-phosphate, was administered together with 17-beta-estradiol 17-beta-acetate on ovariectomized Bom:NMRI mice, the short term effects of the hormone on the uterus aminoacyl-tRNA synthetase phosphatase and aminoacyl-tRNA synthetase activities were reversed, whereas the effect on the liver enzymes was about the same for 17-beta-estradiol 17-beta-acetate and for 2-deoxyadenosine 3-phosphate.