- Application of dibutyltin oxide method to regioselective acylation and alkylation of tylosin at C-4''.
Application of dibutyltin oxide method to regioselective acylation and alkylation of tylosin at C-4''.
Chemical & pharmaceutical bulletin (1989-04-01)
K Kiyoshima, M Sakamoto, T Ishikura, Y Fukagawa, T Yoshioka, H Naganawa, T Sawa, T Takeuchi
PMID2766418
RESUMEN
4''-O-Acyl-, 4''-O-alkyl- and 4''-deoxy-tylosin derivatives were synthesized using 2'-O-acetyl-3'',4''-O-(dibutyl-stannio)tylosin as a synthetic intermediate. The in vitro biological evaluation showed that the new derivatives were active against macrolide-resistant clinical isolates of bacteria and mycoplasmas, and that they were resistant to hepatic esterase.
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