- Total synthesis of (-)-conocarpan and assignment of the absolute configuration by chemical methods.
Total synthesis of (-)-conocarpan and assignment of the absolute configuration by chemical methods.
Chemical communications (Cambridge, England) (2007-05-24)
Derrick L J Clive, Elia J L Stoffman
PMID17520119
RESUMEN
(-)-Conocarpan (1) was synthesized by a method based on radical cyclization, and the absolute configuration was established by chemical degradation; the original 2R,3R-assignment to (+)-conocarpan should be reversed, as suggested by a later chiroptical study of model 2,3-dihydrobenzofurans.
MATERIALES